作者@article {Harasty944 = {jHarasty通用韩礼德和j . Xuereb k Croot h·班尼特和jr霍奇},title ={伴随着音韵学的皮质退化和语义语言障碍在广告},体积={56}={7},页面= {944 - 950}= {2001},doi = {10.1212 / WNL.56.7.944},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:比较皮质变性的模式与不同的语言赤字相关的广告。首页方法:用例的详细neuropathologic分析(例1和2)被选中,因为他们详细的临床和神经心理学评估广告的语言障碍。患者1有严重音韵学的障碍与相对保留语言的语义方面。病人2有严重的语义语言障碍相对保存音韵学的技能。皮质区域的组织体积与语言功能是使用标准化的三维测量技术。神经元面积分数也从组织学测量组织样本。成交量萎缩的程度和神经元损失计算与控制措施(n = 10男性和11个女性)。测量超过2 SD从控制被认为是异常。结果:广告案例都重要的变性颞上回和面积37。皮质语言影响的地区只有在病人1包括前部和后部脑岛和布罗卡{\ textquoteright}年代区域的一部分。 In contrast, Patient 2 had a greater degree of degeneration in the temporal gyri and their white matter connections with the hippocampal/entorhinal complex.Conclusions: Variable patterns of neurodegeneration underlie the clinical differences observed in patients with AD. Disconnection within the temporal lobe appears associated with semantic language difficulties, whereas disconnection of the anterior and posterior language areas appears associated with phonologic and grammatical impairment.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/56/7/944}, eprint = {//www.ez-admanager.com/content/56/7/944.full.pdf}, journal = {Neurology} }