TY - T1的性别和年龄修改APOE之间的关系和AD-related神经病理学JF -神经学乔-神经病学SP - 1696 LP - 1701 - 10.1212 / WNL.56.12.1696六世首页- 56 - 12盟E Ghebremedhin AU - c·舒尔茨盟湄需要非盟-美国摩擦AU - T.G.欧姆AU - E . Braak盟- h . Braak Y1 - 2001/06/26 UR - //www.ez-admanager.com/content/56/12/1696.abstract N2 -目的:评估影响的载脂蛋白E (APOE)多态性AD-related神经原纤维缠结形成和老年斑(非功能性测试)(SP)。方法:对729例行解剖大脑的一个示例(359名男性,370名女性;年龄范围,60到99年)进行了研究。所有的大脑神经病理学分类根据程序允许六个非功能性测试阶段和三个SP的分化阶段。在所有情况下执行APOE基因分型。结果:ε4的APOE等位基因关联不仅与SP (p & lt;0.0001),也非功能性测试的形成(p & lt;0.0001)。ε4等位基因在非功能性测试的效果形成指出年龄≥80岁(p & lt;0.0001),而不是60到79岁之间(p = 0.12)。 An association between the ε4 allele and SP for women was found at ages 60 to 79 years (p < 0.0001) but not at ≥80 years of age (p = 0.063). By comparison, men showed an association in both age categories (p = 0.001 and p = 0.001). Conclusion: The results confirm the association between the ε4 allele and both types of AD-related lesions and show that this association is differentially modified by age and gender. ER -