TY - T1的癫痫患者表现出正常海马体积内嗅皮层萎缩JF -神经学乔-神经病学SP - 1335 LP - 1339 - 10.1212 / WNL.56.10.1335六世- 56 - 10 AU - n;首页 8:32 AU - a; 8:32 AU - z . Caramanos AU - f . Dubeau AU - j·理查森AU - f . Andermann盟D.L.阿诺德Y1 - 2001/05/22 UR - //www.ez-admanager.com/content/56/10/1335.1.abstract N2 -目的:确定MRI体积测量内嗅皮层可以检测结构损伤,使向侧面没收集中在颞叶癫痫患者没有可衡量的海马异常被发现。背景:减少的体积内嗅皮层侧发作的焦点在难治性颞叶癫痫患者和海马萎缩最近被显示。方法:MRI体积内嗅皮层的分析进行了使用t1加权三维梯度回波序列在24对照组和22颞叶癫痫患者和正常海马卷。13个病人进行了手术,术后随访36个月。Results: Group analysis (multivariate analysis of variance) showed a reduction in the volume of the entorhinal cortex ipsilateral to the seizure focus in patients with left (p < 0.0001) and right temporal lobe epilepsy (p < 0.0001). Lateralization of the seizure focus could be done in 14 of 22 patients (64%) based on entorhinal cortex volumetry. Conclusion: Entorhinal cortex atrophy ipsilateral to the seizure focus supports the presence of structural damage in the mesial temporal lobe in patients with temporal lobe epilepsy and normal hippocampal volumes and emphasizes the participation of the entorhinal cortex in the pathogenesis of this disorder. ER -