RT期刊文章SR电子T1相结合的评估τ和神经元线程在阿尔茨海默病脑脊液蛋白质摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP 1498 OP 1504 10.1212 / WNL.54.7.1498 VO 首页54是7 A1 P.J.卡利A1 m . Jakowec A1中华民国Teipel A1 h . Hampel A1通用Petzinger A1 D.A.迪蒙特A1。西尔弗伯格A1周宏儒。穆勒的A1 J.A. Yesavage A1 Jr Tinklenberg A1 E.M.射击A1通用墨菲,Jr .)年2000 UL //www.ez-admanager.com/content/5首页4/7/1498.abstract AB目的:比较研究CSF水平AD7C-neuronal线程的蛋白质和τ(NTP)在AD患者和对照组。背景:广告神经原纤维缠结的特点是由异常过度磷酸化microtubule-associated蛋白质τ。AD7C-NTP是一个提出广告标志表示在神经原纤维退行性变的早期阶段。方法:酶联免疫吸附测定特定τ和AD7C-NTP。脑脊液样本来自35个精神错乱的患者(25临死前的临床诊断可能的广告,5 neuropathologic诊断明确的广告,与路易体病理5),29日nondemented PD患者和16个老年健康对照组。接受者操作特征(ROC)和多元判别分析广告与控制。相关分析脑脊液τAD7C-NTP和细微精神状态检查的每一个标记(MMSE)得分。结果:水平的τ和AD7C-NTP都在AD患者与对照组相比显著升高。ROC分析表明,CSFτ区分广告和nondemented对照组患者敏感性63%,特异性89%,AD7C-NTP敏感性70%,特异性87%。 Combined evaluation of both markers with discriminant analysis raised the specificity to 93% at a 63% sensitivity level. Both markers positively correlated with each other within the AD group, but not among control subjects. CSF levels of AD7C-NTP, but not of tau, showed a small but significant inverse correlation (r = −0.43) with MMSE scores of AD patients. Conclusions: CSF levels of tau and AD7C-NTP may be useful biomarkers for AD.

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