PT -期刊文章盟P.J.卡利AU - m . Jakowec盟中华民国Teipel AU - h . Hampel AU -通用Petzinger盟D.A.迪蒙特盟周宏儒——国民生产总值Silverberg盟。穆勒AU - j Yesavage盟E.M.射击- Jr Tinklenberg盟盟——通用墨菲,Jr . TI -综合评估神经线程的蛋白质和τ的阿尔茨海默病脑脊液援助- 10.1212 / WNL.54.7.1498 DP - 2000年4月11日TA -神经病学第六PG - 1498 - 1504 - 54 IP - 7 4099 - //www.ez-admanager.com/content/54/7/1498.short 4100 - 首页//www.ez-admanager.com/content/54/7/1498.full Neurology2000 4月11日;54 AB -目的:比较研究CSF水平AD7C-neuronal线程的蛋白质和τ(NTP)在AD患者和对照组。背景:广告神经原纤维缠结的特点是由异常过度磷酸化microtubule-associated蛋白质τ。AD7C-NTP是一个提出广告标志表示在神经原纤维退行性变的早期阶段。方法:酶联免疫吸附测定特定τ和AD7C-NTP。脑脊液样本来自35个精神错乱的患者(25临死前的临床诊断可能的广告,5 neuropathologic诊断明确的广告,与路易体病理5),29日nondemented PD患者和16个老年健康对照组。接受者操作特征(ROC)和多元判别分析广告与控制。相关分析脑脊液τAD7C-NTP和细微精神状态检查的每一个标记(MMSE)得分。结果:水平的τ和AD7C-NTP都在AD患者与对照组相比显著升高。 ROC analysis showed that CSF tau distinguished between patients with AD and nondemented control subjects with 63% sensitivity and 89% specificity, AD7C-NTP with 70% sensitivity and 87% specificity. Combined evaluation of both markers with discriminant analysis raised the specificity to 93% at a 63% sensitivity level. Both markers positively correlated with each other within the AD group, but not among control subjects. CSF levels of AD7C-NTP, but not of tau, showed a small but significant inverse correlation (r = −0.43) with MMSE scores of AD patients. Conclusions: CSF levels of tau and AD7C-NTP may be useful biomarkers for AD.

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