TY -的T1神经病学学术面貌改变JF -神经学乔-神经病学SP - 906 LP - 9首页06 - 10.1212 / WNL.53.5.906六世- 53 - 5盟Timothy a佩德利说Y1 - 1999/09/01 UR - //www.ez-admanager.com/content/53/5/906.abstract N2 -这是最好的时代;这是最坏的时代。这是智慧的时代,这是愚蠢的时代。这是信仰的时期;这是怀疑的时期;这是光明的季节;这是黑暗的季节。这是希望的春天;这是绝望的冬天。我们以前的一切; we had nothing before us.The introduction of Charles Dickens’ A Tale of Two Cities describes the state of medical affairs today as much as the tumultuous world of the French Revolution 200 years ago. On the one hand, advances in basic and clinical neuroscience are transforming our field. The following list includes topics unknown or in their infancy 30 years ago, when I was graduated from medical school, which are now central to the neurology research effort. • CNS neurotransmitters (other than γ-amino-butyric acid, acetylcholine) • Receptors and mechanisms of receptor actions • Ion channels and membrane biophysics • Intercellular and intracellular communication • Cell death: necrosis, apoptosis • Nonsynaptic cell–cell interactions • Realistic computer modeling of neuronal networks • Biochemical and molecular genetics; cell biology The last 10 years have also seen a great expansion in the following number of areas and topics considered appropriate for research support.1 • Epidemiology • Experimental therapeutics • Disease prevention strategies • Quality of life issues • Behavioral/psychological issues • Health services research (quality assessment, cost-effectiveness, outcome research, decision analysis, and quality assessment) • Models for delivery of medical care (primary physician to neurologic center) • Ethics of clinical policies and research As a specialty, we are riding a tidal wave of understanding fundamental mechanisms and advances in therapeutics that is simply unparalleled. The pace at which new information appears is rapid and far-reaching. The wonderful … ER -