PT -期刊文章盟y Harati AU - c·古奇AU - m·斯文森盟- s . Edelman AU - d·格林非盟- p·拉斯金盟-多诺弗里奥p . AU - d Cornblath AU - r . Sachdeo AU - c . o . Siu AU - m·TI -双盲随机试验等曲马多治疗糖尿病神经病变的痛苦的援助- 10.1212 / WNL.50.6.1842 DP - 1998 1846年6月01 TA -神经病学PG - 1842——VI - 50 IP - 6 4099 - //www.ez-admanager.com/content/50/6/1842.short 4100 - //www.ez-admanager.com/content/50首页/6/1842.full所以Neurology1998 6月01;50 AB -目的本研究的目的是评估的有效性和安全性曲马多治疗糖尿病神经病变的痛苦。背景糖尿病神经病变的痛苦是这些患者中发病率的主要原因和治疗,与其它small-fiber神经病变,往往是令人不满意的。曲马多是集中代理镇痛用于治疗中度至中等严重疼痛。方法这个多中心、门诊、随机、双盲、安慰剂对照,与这些相应平行的组织研究由一个washoutlscreening阶段,在此期间所有止痛药都停产了,和42天双盲治疗期的阶段。共有131个痛苦的糖尿病神经病变患者治疗曲马多(n = 65)或安慰剂(n = 66)曲马多,划分管理胶囊相同的剂量每天四次。主要功效分析比较了平均疼痛强度评分曲马多和安慰剂组获得了42天的研究或停止的时候。次要疗效评估疼痛等级分数和生活质量评估基于日常活动和睡眠特征。结果曲马多,平均剂量为210毫克/天,明显(p & lt;0.001)比安慰剂更有效治疗糖尿病神经病变的痛苦。 Patients in the tramadol group scored significantly better in physical (p = 0.02) and social functioning (p = 0.04) ratings than patients in the placebo group. No statistically significant treatment effects on sleep were identified. The most frequently occurring adverse events with tramadol were nausea, constipation, headache, and somnolence. Conclusions The results of this placebo-controlled trial showed that tramadol was effective and safe in treating the pain of diabetic neuropathy.

map