TY -的T1 -神经元烟碱乙酰胆碱受体抗体进入亚急性自主神经病变和癌症相关综合症JF -神经学乔-神经病学SP - 1806 LP - 1813 - 10.1212 / WNL.50.6.1806六世- 50 - 6盟史蒂文Vernino AU首页 -吉尔亚当斯基盟Thomas j . Kryzer AU -罗伯特d . Fealey盟万带兰a列侬Y1 - 1998/06/01 UR - //www.ez-admanager.com/content/50/6/1806.abstract N2 -背景自身抗体特定的乙酰胆碱受体(乙酰胆碱受体)骨骼肌(包含α1亚基)损害神经肌肉传导在重症肌无力(MG)。乙酰胆碱受体介导快速通过自主神经节突触传递结构类似于肌肉乙酰胆碱受体,但包含α3亚基。我们建议神经节的乙酰胆碱受体自身免疫可能引起神经异常。客观测试的自主神经病变患者血清神经元神经节乙酰胆碱受体特异性自身抗体。我们开发了一个免疫沉淀反应放射性分析的方法络合epibatidine(125标高亲和力受体激动剂)特里同x - 100可溶性乙酰胆碱受体从边缘神经母细胞瘤细胞膜抗原。鼠单克隆免疫球蛋白(免疫球蛋白)特定的肌肉或神经乙酰胆碱受体验证试验的特异性。我们测试了从52名健康受试者血清,与亚急性自主神经病变12例,与其他神经系统疾病248例。结果12例患者抗体绑定明确神经节乙酰胆碱受体。五个亚急性自主神经病变,和三个测试(六)Isaacs综合症;四个八有癌(肺、膀胱、直肠、甲状腺)。 The remaining four seropositive patients (two Lambert-Eaton syndrome, one dementia, one sensory neuronopathy) all had Ca2+ channel antibodies and three had small cell lung carcinoma. No healthy subject had ganglionic AChR antibodies, nor did 62 patients with MG and muscle AChR antibodies. Conclusion Neuronal AChR antibodies are a novel serologic marker of neurologic autoimmunity. The pathogenicity of neuronal AChR autoantibodies in autonomic neuropathy, Isaacs' syndrome, or other neurologic disorders remains to be shown, as has been demonstrated for muscle AChR antibodies in MG. An autoimmune and potentially paraneoplastic etiology is implicated in seropositive patients. ER -