TY - T1的多种和肿瘤的病人血清反应阳性的1型antineuronal核自身抗体JF -神经学乔-神经病学SP - 652 LP - 657 - 10.1212 / WNL.50.3.652六世- 50 - 3盟——克劳迪娅·f·Lucchinetti A首页U -大卫·w·Kimmel盟万带兰a列侬Y1 - 1998/03/01 UR - //www.ez-admanager.com/content/50/3/652.abstract N2 - 1型antineuronal核自身抗体(ANNA-1,也称为“anti-Hu”)是一个标记的神经系统自身免疫性高度与小细胞肺癌(SCLC)。确定症状和体征的光谱的频率以及成人癌症患者血清反应阳性的ANNA-1,我们回顾了162个连续的患者(67%的女性)确认为ANNA-1-positive全面免疫荧光筛选试验。在这些患者的21%,抗体测试要求的医生不是ANNA-1。的随访期间,癌症被发现在142名患者(88%)。10这些缺乏证据的SCLC(4有前列腺癌,3乳房癌,1前列腺癌和黑色素瘤,淋巴瘤,1和1肺鳞状细胞癌)。证明SCLC的132名患者(81%),17岁有一个或多个共存的恶性肿瘤(6肾癌,4另一个肺原发性癌,3前列腺癌,3乳腺癌和4各种肿瘤)。SCLC诊断的128例患者(97%)出现多种症状。SCLC被确定在10个病人胸部核磁共振后一个模棱两可的胸片和CT;支气管镜检查在28、纵隔镜检查或开胸;和7尸检。 Neurologic signs in decreasing frequency were neuropathy (sensory> mixed somatic > autonomic > cranial [especially cranial nerve VIII] > motor), cerebellar ataxia, limbic encephalitis, polyradiculopathy, associated Lambert-Eaton myasthenic syndrome, myopathy, myelopathy, opsoclonus/myoclonus, motor neuronopathy, brachial plexopathy, and aphasia. Nineteen patients had a solely gastrointestinal initial presentation, including gastroparesis, pseudo-obstruction, esophageal achalasia, or other dysmotility. We conclude that seropositivity for ANNA-1 can expedite the diagnosis and treatment of otherwise occult cancer in patients, especially tobacco abusers, with varied neurologic and gastroenterologic presentations. The search for SCLC should not end on discovering a different neoplasm. ER -