% 0期刊文章%克劳迪娅·f·Lucchinetti % Kimmel David w . %万带兰A·列侬% T多种肿瘤的病人血清反应阳性的1型antineuronal核自身抗体% D 1998% R 10.1212 / WNL.50.3.652 % J神经病学% 652 - 657 P % V 50% N 3% X 1型antineuronal核自身抗体(ANNA-1,也称为“anti-Hu”)是一个标记的神经系统自身免疫性高度与小细胞肺癌(SCLC)。首页确定症状和体征的光谱的频率以及成人癌症患者血清反应阳性的ANNA-1,我们回顾了162个连续的患者(67%的女性)确认为ANNA-1-positive全面免疫荧光筛选试验。在这些患者的21%,抗体测试要求的医生不是ANNA-1。的随访期间,癌症被发现在142名患者(88%)。10这些缺乏证据的SCLC(4有前列腺癌,3乳房癌,1前列腺癌和黑色素瘤,淋巴瘤,1和1肺鳞状细胞癌)。证明SCLC的132名患者(81%),17岁有一个或多个共存的恶性肿瘤(6肾癌,4另一个肺原发性癌,3前列腺癌,3乳腺癌和4各种肿瘤)。SCLC诊断的128例患者(97%)出现多种症状。SCLC被确定在10个病人胸部核磁共振后一个模棱两可的胸片和CT;支气管镜检查在28、纵隔镜检查或开胸;和7尸检。 Neurologic signs in decreasing frequency were neuropathy (sensory> mixed somatic > autonomic > cranial [especially cranial nerve VIII] > motor), cerebellar ataxia, limbic encephalitis, polyradiculopathy, associated Lambert-Eaton myasthenic syndrome, myopathy, myelopathy, opsoclonus/myoclonus, motor neuronopathy, brachial plexopathy, and aphasia. Nineteen patients had a solely gastrointestinal initial presentation, including gastroparesis, pseudo-obstruction, esophageal achalasia, or other dysmotility. We conclude that seropositivity for ANNA-1 can expedite the diagnosis and treatment of otherwise occult cancer in patients, especially tobacco abusers, with varied neurologic and gastroenterologic presentations. The search for SCLC should not end on discovering a different neoplasm. %U //www.ez-admanager.com/content/neurology/50/3/652.full.pdf