TY -的T1 -抗白细胞粘附疗法JF -神经学乔-神经病学SP - S32 LP - - 10.12首页12 / WNL.49.5_Suppl_4 S38做。S32六世- 49 -生理4 AU -韦恩·m·克拉克盟贾斯汀a Zivin Y1 - 1997/11/01 UR - //www.ez-admanager.com/content/49/5_Su首页ppl_4/S32.abstract N2 -白细胞似乎加强中枢神经系统通过阻塞微循环再灌注损伤并渗透到大脑,在那里他们神经元释放自由基和其他有毒物质。这些过程的第一步是内皮细胞粘附白细胞。微循环障碍和脑渗透可以减少使用特定单克隆抗体针对白细胞粘附受体。实验研究发现降低中风损害当抗体结合CD-18白细胞粘附分子或其配体上的内皮细胞,细胞间粘附molecule-1 (ICAM-1)。这里我们回顾内皮粘附白细胞的组件,抗白细胞粘附制剂的临床前研究、临床前研究调查结合防粘与溶栓治疗。白细胞与内皮细胞的粘附。白细胞的迁移从血液进入大脑是一个多步骤的过程。首先,主要leukocyte-endothelial交互(滚动)发生。这个过程是由P-selectin表面E-selectin内皮细胞和通过L-selectin leukocytes1(图1)。在激活,公司奉行的内皮细胞白细胞(粘)随后由白细胞膜glyco-protein受体复杂,称为CD-18或β2-integrin及其内皮配体、icam - 1.2, 3 CD-18整合素复杂的包含三个形成。 All three share an identical β-subunit(also frequently called CD-18) and are distinguished from each other by distinct α-subunits. The three α-subunits are termed leukocyte function antigen (LFA-1 or CD-11a, present on all leukocytes), MAC-1 (CD-11b, present mostly on PMNs and monocytes), and P150 (CD-11c, present on neutrophils and monocytes). The corresponding counter-receptors for the CD-18 integrin complex are the ICAM family of adhesion molecules. Whereas ICAM-1 is widely expressed on many cells and binds to LFA-1 and MAC-1, ICAM-2 is expressed only on endothelial cells and leukocytes and is recognized only by LFA-1.4 Unlike … ER -