泰的T1 -摩根富林明中风管理进展神经学乔-神经病学SP - S1 LP - S2 - 10.121首页2 / WNL.49.5_Suppl_4。S1六世- 49 - 5 4 AU -大卫·g·谢尔曼Y1 - 1997/11/01 UR - //www.ez-admanager.com/content首页/49/5_Suppl_4/S1.abstract N2 -传统上,血白细胞正常功能被认为是一个至关重要的元素,没有身体的生存就会受到威胁。白细胞保护我们免受入侵的微生物。如果没有他们,我们将很容易落入否则良性感染的致命攻击。在过去的几年中我们已经意识到白细胞反应多种组织损伤,包括缺血,他们实际上可能导致和加重组织损伤。当组织损伤,如缺血发生时,信号出现在内皮微脉管系统的吸引白细胞的地区缺血性脑损伤。白细胞在血管的血液循环经过大脑缺血。他们被迫徘徊,附着在内皮,扁平,穿透内皮受伤的缺血性组织。我们现在知道,有各种各样的白细胞表面的受体,有能力应对内皮受体网站。在这些受体是细胞间粘附molecule-1 (ICAM-1)位于内皮细胞。 Leukocyte adhesion and migration require the interaction of ICAM-1 on the endothelium with CD11/CD18 leukocyte integrins on the surface of neutrophils. As leukocytes and monocytes adhere to the vessel wall, they can release damaging cytokines including IL-1, IL-2, and tissue necrosis factor alpha(TNF-α). These cytokines become proinflammatory and can promote thrombosis by binding circulating anticoagulants, such as protein S, and inhibiting tissue plasminogen activator release. Some of the early basic observations that led to an understanding of this process grew out of the … ER -