泰的T1 -摩根富林明罗匹尼罗的药物简介神经学乔-神经病学SP - S58 LP - - 10.1212 / W首页NL.49.1_Suppl_1 S62做。S58六世- 49 - 1 5 1 AU -伊恩·f·洛克Y1 - 1997/07/01 UR - //www.ez-admanager.com/cont首页ent/49/1_Suppl_1/S58.abstract N2 -使用多巴胺受体激动剂作为单一疗法或结合左旋多巴治疗帕金森病(PD)允许或限制减少左旋多巴的剂量,可能推迟发病或减少电动机后期并发症的严重程度。Ropinirole is a new nonergoline dopamine agonist that binds specifically to D2-like receptors with a selectivity similar to that of dopamine (D3 > D2 > D4). The chemical structure of ropinirole has the potential to maintain a structure-activity relationship similar to that of dopamine and other effective dopamine agonists without producing ergot-related adverse effects. Ropinirole has demonstrated efficacy in two standard preclinical models of PD and has shown a very low propensity to induce dyskinesia in these studies. This latter property is of potential clinical importance for pharmacotherapy of early PD. This article will present the importance of pharmacologic specificity of dopamine agonists along with the basic pharmacologic characteristics of ropinirole that may contribute to its efficacy in the treatment of PD. ER -