TY -的T1的障碍是什么选择准确的临床诊断的疾病?JF -乔神经学临床病理的研究神经病学SP - 62 LP -首页 69 - 10.1212 / WNL.49.1.62六世- 49 - 1 AU - i Litvan盟y Agid AU - n . Sastrj AU - j .扬科维奇AU - g·k .温家宝AU - c . g . Goetz AU - m . Verny盟j.p. Brandel AU - k .定形盟k . Ray乔杜里盟——A·麦基盟e·c·赖AU - r·k·b·皮尔斯盟j。j Bartko Y1 - 1997/07/01 UR - //www.ez-admanager.com/content/49/1/62.abstract N2 -几项研究已经评估的可靠性和有效性的临床诊断阿尔茨海默病(AD)使用定义良好的neuropathologic标准,但没有人试图评估选择的疾病的诊断准确性。我们决定选择的临床诊断的准确性,提出105 autopsy-confirmed病例选择的(n = 7)和相关疾病(non-Pick, n = 98)作为临床小品文的顺序是随机的,以六个神经病学家知道验尸结果。评级机构的组中度到公平协议选择的衡量的诊断κ统计数据。诊断的敏感性的选择的第一次访问(意思是,53个月后开始)和最后一次访问(意思是,78个月后开始)很低(范围,0到71%),但特异性是近乎完美的。中等阳性预测值在访问都是85%到83。假阴性误诊主要涉及广告。假阳性诊断罕见,发生corticobasal变性(第一次)和路易体痴呆与(最后一次访问)。选择也被误诊的主要神经学家。最好的临床预测痴呆早期诊断的选择包括“额”,早期皮质痴呆严重额叶干扰,没有失用症,缺乏步态障碍的发病。 However, the first neurologic evaluation in some of the Pick's cases took place in advanced stages of the disease. Our findings suggest that this disorder is underdiagnosed in clinical practice. Although the low sensitivity for the clinical diagnosis of Pick's is disappointing, our data suggest that when clinicians suspect Pick's, their diagnosis is almost always correct. Absence of awareness of the main features of this disorder and of specificity of the frontal lobe syndrome may partially explain the low detection of Pick's disease. ER -