TY - T1的载脂蛋白E基因增强子地区新发现的多态性与老年痴呆症和强烈ε4等位基因JF -神经学乔-神经病学SP - 196 LP - 201 - 10.1212 / WNL.47.1.196六世- 47 - 1 AU -美国梅AU - m·布里格斯盟- h .钟AU - r·b·华莱士AU - t . Gomez-Isla AU - g . w首页 .三弦琴AU - b·t·海曼Y1 - 1996/07/01 UR - //www.ez-admanager.com/content/47/1/196.abstract N2 -载脂蛋白E等位基因4 (apoEε4)迟发性的广告是一个主要的危险因素。遗传的等位基因与痴呆的发病年龄较早的在个人广告。还不知道其他的apoE基因多态性可能影响apoEε4对广告的影响。我们筛选了部分发起人apoE受体结合域的增强子元素和其他多态性可能影响广告的风险。特别是在位置+ 113 C / G多态性apoE mRNA的apoE基因内区1增强子元素(IE1)最近被确定。我们没有发现其他的多态性。我们研究的关系IE1的两个等位基因多态性与广告,发现明显IE1 G和广告之间的联系(n = 94;p = 0.0515)。However, the IE1 G allele is also closely associated with apoE epsilon 4 (p < 0.0001). When the presence of apoE epsilon 4 is covaried, the association between the IE1 G allele and AD is no longer statistically significant (odds ratio = 1.29, 95% confidence interval: 0.44, 3.78). In contrast, epsilon 4 is still highly associated with AD when IE1 G is controlled for (odds ratio = 5.91, 95% confidence interval: 3.29, 10.63). Furthermore, there is no significant association between the age of onset of dementia and the inheritance of the G allele. We believe that the apparent association between IE1 G and AD is a consequence of the association between the epsilon 4 and IE1 G alleles. NEUROLOGY 1996;47: 196-201 ER -