% 0期刊文章% s梅% m·布里格斯% h .涌%一个R·b·华莱士% T . Gomez-Isla % g . w .三弦琴% b·T·海曼% T载脂蛋白E基因增强子地区新发现的多态性与老年痴呆症和强烈ε4等位基因% D R 10.1212 / 1996% WNL.47.1.196 % J神经病学% P 196 - 201 V % 47% N X载脂蛋白E等位基因4 1% (apoEε4)迟发性的广告是一个主要的危险因素。首页遗传的等位基因与痴呆的发病年龄较早的在个人广告。还不知道其他的apoE基因多态性可能影响apoEε4对广告的影响。我们筛选了部分发起人apoE受体结合域的增强子元素和其他多态性可能影响广告的风险。特别是在位置+ 113 C / G多态性apoE mRNA的apoE基因内区1增强子元素(IE1)最近被确定。我们没有发现其他的多态性。我们研究的关系IE1的两个等位基因多态性与广告,发现明显IE1 G和广告之间的联系(n = 94;p = 0.0515)。然而,IE1 G等位基因也与apoEε4密切相关(p < 0.0001)。当apoEε4是共变的存在,IE1 G等位基因和广告之间的关系不再是统计学意义(or = 1.29, 95%置信区间:0.44 - 3.78)。 In contrast, epsilon 4 is still highly associated with AD when IE1 G is controlled for (odds ratio = 5.91, 95% confidence interval: 3.29, 10.63). Furthermore, there is no significant association between the age of onset of dementia and the inheritance of the G allele. We believe that the apparent association between IE1 G and AD is a consequence of the association between the epsilon 4 and IE1 G alleles. NEUROLOGY 1996;47: 196-201 %U //www.ez-admanager.com/content/neurology/47/1/196.full.pdf