作者@article {Mui196 ={年代。梅·m·布里格斯和h .涌r·b·华莱士和t . Gomez-Isla g . w .三弦琴和b·t·海曼}title ={新发现多态性与载脂蛋白E基因增强子地区{\ textquoteright}年代老年痴呆症和强烈ε4等位基因},体积={47}={1},页面= {196 - 201}= {1996},doi = {10.1212 / WNL.47.1.196},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={载脂蛋白E等位基因4 (apoEε4)迟发性的广告是一个主要的危险因素。首页遗传的等位基因与痴呆的发病年龄较早的在个人广告。还不知道其他的apoE基因多态性可能影响apoEε4对广告的影响。我们筛选了部分发起人apoE受体结合域的增强子元素和其他多态性可能影响广告的风险。特别是在位置+ 113 C / G多态性apoE mRNA的apoE基因内区1增强子元素(IE1)最近被确定。我们没有发现其他的多态性。我们研究的关系IE1的两个等位基因多态性与广告,发现明显IE1 G和广告之间的联系(n = 94;p = 0.0515)。然而,IE1 G等位基因也与apoEε4密切相关(p < 0.0001)。 When the presence of apoE epsilon 4 is covaried, the association between the IE1 G allele and AD is no longer statistically significant (odds ratio = 1.29, 95\% confidence interval: 0.44, 3.78). In contrast, epsilon 4 is still highly associated with AD when IE1 G is controlled for (odds ratio = 5.91, 95\% confidence interval: 3.29, 10.63). Furthermore, there is no significant association between the age of onset of dementia and the inheritance of the G allele. We believe that the apparent association between IE1 G and AD is a consequence of the association between the epsilon 4 and IE1 G alleles. NEUROLOGY 1996;47: 196-201}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/47/1/196}, eprint = {//www.ez-admanager.com/content/47/1/196.full.pdf}, journal = {Neurology} }