PT -期刊文章盟詹姆斯·r·佩里AU -艾伦·华纳TI -瞬态后脑病紫杉醇(紫杉醇)注入援助- 10.1212 / WNL.46.6.1596 DP - 1996年6月01 TA -神经病学PG - 1596——1599 VI - 46 IP - 6 4099 - //www.ez-admanager.com/content/46/6/159首页6.short 4100 - //www.ez-admanager.com/content/46/6/1596.full所以Neurology1996 6月01;46 AB -紫杉醇(紫杉醇)是一种新型的抗肿瘤药,通过促进微管聚合行为。虽然myelosuppression和外围神经毒性是众所周知的和剂量限制,没有中枢神经系统毒性的报道,除了两个癫痫患者。这或许反映出,紫杉醇有很少或没有血脑屏障渗透。我们报告两个女人接受紫杉醇开发临床状态混乱,种种困难,和行为的变化。有双边伸肌足底反应。这些症状出现后1周紫杉醇注入和自发的解决。后续注入与类似self-resolving脑病有关一个病人和复发性头痛和共济失调。神经影像学(包括增强MRI)、LP和实验室调查并没有透露其他原因。脑电图显示弥漫性非特异性放缓。 One MRI had prominent but nonspecific high signal intensity abnormalities in the deep white matter of the cerebral hemispheres. Based on temporal association, diagnostic exclusion, and repeated episodes with subsequent challenges, we believe these patients may have experienced CNS toxicity from paclitaxel. The mechanism for this self-resolving encephalopathic process is unclear. NEUROLOGY 1996;46: 1596-1599