PT -期刊文章AU - r . l .张盟- m . Chopp AU - w x唐盟李振国张盟- s·d·帕特尼盟r . m . Starzyk TI -百日咳杆菌合成肽来源于< em > < / em >细菌减少梗塞体积在大鼠短暂性大脑中动脉闭塞后援助- 10.1212 / WNL.46.5.1437 DP - 1996 1437年5月01 TA -神经病学PG - 1437——VI - 46 IP - 5 4099 - //www.ez-admanager.com/content/46/5/1437.short 4100 - //www.ez-admanager.com/content/46/5/1437.full所以Neurology1996可能01;首页46 AB -我们探索肽的治疗潜力(F20)派生从丝状的百日咳博德特氏菌血凝素模型缺血性细胞损伤后的瞬态(2小时)大脑中动脉(MCA)闭塞的老鼠。动物分为两组——(1)F20肽组:大鼠(n = 11)受到瞬态MCA闭塞2小时,或者F20肽静脉注射(50 nmol)在0小时再灌注和腹腔内(150 nmol /剂量),2,4,6,8,22日和30个小时再灌注;(2)组:大鼠(n = 10)管理F23肽(肽F20)炒的版本相同的实验协议F20肽组。46个小时再灌注后,动物牺牲,脑组织与氯化三苯基四氮唑染色组织损伤的评价。测量中性粒细胞数量缺血性组织髓过氧化物酶(MPO)免疫染色进行冠状脑部分在每一个动物。There was a significant reduction of ischemic infarct volume (36%, p <0.05) in the F20 group of animals compared with the F23 group. The area of the ischemic lesion was highly correlated with the numbers of the immunoreactive MPO cells (r = 0.78, p <0.001). The data demonstrate that the F20 peptide significantly reduces infarct volume and intraparenchymal neutrophil numbers after transient MCA occlusion.