TY - T1的地形单边mesiotemporal癫痫发作葡萄糖代谢减退的JF -神经学乔-神经病学SP - 1422 LP - 1422 - 10.1212 / WNL.46.5.1422六世- 46 - 5首页非盟- s阿诺德盟- g . Schlaug AU - h . Niemann AU - a . it AU - h . Luders AU - o·w·威特AU - r·j·塞茨Y1 - 1996/05/01 UR - //www.ez-admanager.com/content/46/5/1422.abstract N2 -我们映射区域脑葡萄糖代谢(rCMRGlu) 20例患有医学上难治性局灶性癫痫的左或右mesiotemporal起源(mTLE)清醒。颞叶切除术后,组织学证实18例海马硬化。Pixel-by-pixel comparisons with healthy control subjects showed significant (p <0.001) depressions of the mean rCMRGlu ipsilateral to the epileptic focus in the mesiotemporal region, including the hippocampus and the parahippocampal gyrus and middle temporal gyrus. Additional remote rCMRGlu depressions occurred bilaterally in the fronto-orbital cortex and ipsilaterally in the posterior insula and the thalamus. Patients with left-sided mTLE had additional rCMRGlu depressions in the left inferior frontal gyrus (Broca's region) and superior temporal gyrus at the parietotemporal junction, whereas corresponding rCMRGlu depressions were not present in patients with right mTLE. Neuropsychological testing showed impaired verbal fluency, verbal intelligence, and verbal memory in the left mTLE patients. Correlations of the specific mean rCMRGlu depressions and the neuropsychological deficits suggest that impaired language functions in patients with left mTLE could result from functional changes beyond the temporal lobe. ER -