作者@article {Visser522 = {W。h·维瑟和k·b·克莱因和r·c·考克斯和d·琼斯和M。D法拉利},title ={311人私下偷偷收藏盒式、一个新的中央和周边地表演5-HT1D受体激动剂在急性口服治疗偏头痛},体积={46}={2},页面= {522 - 526}= {1996},doi = {10.1212 / WNL.46.2.522},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={311人私下偷偷收藏盒式是小说,集中和外围地,5 -羟色胺(1 D)受体激动剂。首页我们调查的有效性和安全性,5日和25毫克口服311人私下偷偷收藏盒式急性治疗偏头痛的随机、双盲、安慰剂对照,与这些相应平行的组织涉及84名患者的临床试验。头痛的病人的比例提高了在2小时内从中度或重度轻微或没有痛苦(主要疗效指标)15 \ %接受安慰剂的患者和27 \ %(1毫克),62 \ %(5毫克),和81 \ %(25毫克)患者311人私下偷偷收藏盒式。治疗与安慰剂比较的差异是12 \ % (95 \ % CI - 12, 37;p = 0.460)为1毫克311人私下偷偷收藏盒式,47 \ % (CI 21, 73;p小于0.005)5毫克311人私下偷偷收藏盒式,和66 \ % (CI 43, 89年,p小于0.001)311人私下偷偷收藏盒式25毫克。311年之后人私下偷偷收藏盒式畏光和恶心还显示改进。不良事件通常是在所有治疗组轻度和短暂的。 There were no clinically significant changes in ECG recordings, blood pressure, or laboratory tests. Oral 311C90 (5 and 25 mg) is highly effective and well tolerated in the acute treatment of migraine. The response rates and treatment differences compared with placebo in this study suggest possible superiority over existing antimigraine therapies. This needs to be confirmed in formal comparative trials. NEUROLOGY 1996;46: 522-526}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/46/2/522}, eprint = {//www.ez-admanager.com/content/46/2/522.full.pdf}, journal = {Neurology} }