TY - T1的拉斯穆森的脑炎和新帽子JF -神经学乔-神经病学SP - 9 LP - 11 - 10.1212 / WN首页L.46.1.9六世- 46 - 1 AU -杰克p . Antel盟西奥多·拉斯穆森Y1 - 1996/01/01 UR - //www.ez-admanager.com/content/46/1/9.abstract N2 -神经学1996;46:9-11原型的综合征现在被指定为拉斯穆森脑炎被确定在1941年在一个7岁的男孩发达右侧癫痫发作和随后轻微的右臂无力;左皮质活检显示脑炎。[1]在1945年的时候,他就发展到中度进行性加重。更大的皮质切除再次表明炎症。发作持续右侧偏瘫和偏盲进化。左大脑半球切除术1956年执行;稀疏的血管周的炎症和神经胶质结节被发现。怀尔德潘菲尔德博士咨询在这种情况下,提出的问题继续争论至今。是脑炎的过程的主要异常或反复发作继发反应?为什么一个脑炎的过程应该单方面? Can recurrent seizures lead to tissue destruction? Dr. Penfield, skeptical of the postulate that the syndrome was a primary inflammatory disorder, offered a new hat to anyone who proved him wrong. The clinicopathologic syndrome of childhood-adolescent onset of unilateral seizure disorder with progressive hemiplegia consequent to focal cortical inflammation and tissue destruction has now been recognized and described worldwide. The complete spectrum of the syndrome in terms of age of onset, rate of evolution, topographic distribution of pathology, natural course, and response to therapy continues to be debated. In the series of 48 cases from the Montreal Neurological Hospital reviewed by Oguni et al, [2] the mean age of disease onset was 7 years (range, 1-15 yr), one patient was aged 30 years. The series included cases that stabilized spontaneously and at least one case that improved; these observations create a dilemma in evaluating open-label therapy claims. Neuroimaging done serially on patients demonstrates progressive tissue destruction, but to date this measure has not been included in therapeutic outcome assessments. Pathologic studies of cases with serial samples collected from repeated surgery and … ER -