PT -期刊文章盟亨氏Krestel AU -大卫·r·Schreier盟Elmaze Sakiri AU - Andreas von Allmen盟Yasmina Abukhadra盟Arto Nirkko盟Maja Steinlin AU - Felix罗斯诺夫盟符文Markhus AU -戈比施耐德盟卡罗琳Jagella AU -约翰内斯·马修斯盟哈尔Blumenfeld TI -发作痫性放电的预测能力- 10.1212 / WNL Fitness-to-Drive评估援助。0000000000207531 DP - 2023年8月29日TA -神经病首页学PG - e866 e878 VI - 101 IP - 9 4099 - //www.ez-admanager.com/content/101/9/e866.short 4100 - //www.ez-admanager.com/content/101/9/e866.full所以Neurology2023 8月29日;101 AB -背景和目标本研究旨在评估和预测发作痫性放电的影响(ied)驾驶能力测试和驾驶模拟器使用简单的反应。方法不同的癫痫病患者评估同时脑电图在单闪灯测试他们对视觉刺激的反应,汽车视频游戏和现实的驾驶模拟器。反应时间(RTs)和错过的反应或崩溃(小姐/崩溃)在正常脑电图和简易爆炸装置测量。简易爆炸装置,在这项研究中,考虑一系列的癫痫样的潜力(潜在的在1),分为广义典型,广义非典型或焦点。RT和小姐/崩溃与简易爆炸装置类型、持续时间和测试类型进行了分析。RT延长,小姐/碰撞概率,比值比(或)小姐/事故由于计算简易爆炸装置。结果广义典型的ied RT延长了164 ms,而广义非典型ied (77.0 ms)和焦ied (48.0 ms) (p & lt;0.01)。广义典型简易爆炸装置有一个会话小姐/事故的概率14.7%焦和广义非典型ied零值(p & lt;0.01)。 Long repetitive bursts of focal IEDs lasting >2 seconds had a 2.6% miss/crash probabilityIED. Cumulated miss/crash probability could be predicted from RT prolongation: 90.3 ms yielded a 20% miss/crash probability. All tests were nonsuperior to each other in detecting miss/crash probabilitiesIED (zero median for all 3 tests) or RT prolongations (flash test: 56.4 ms, car-driving video game: 75.5 ms, simulator 86.6 ms). IEDs increased the OR of miss/crash in the simulator by 4.9-fold compared with normal EEG. A table of expected RT prolongations and miss/crash probabilities for IEDs of a given type and duration was created.Discussion IED-associated miss/crash probability and RT prolongation were comparably well detected by all tests. Long focal IED bursts carry a low risk, while generalized typical IEDs are the primary cause of miss/crash. We propose a cumulative 20% miss/crash risk at an RT prolongation of 90.3 ms as a clinically relevant IED effect. The IED-associated OR in the simulator approximates the effects of sleepiness or low blood alcohol level while driving on real roads. A decision aid for fitness-to-drive evaluation was created by providing the expected RT prolongations and misses/crashes when IEDs of a certain type and duration are detected in routine EEG.10%–90% IPR=10%–90% interpercentile range; Gen atyp=generalized atypical (IEDs); Gen typ=generalized typical (IEDs); IEDs=interictal epileptiform discharges; miss/crash=missed reactions or crashes; RTs=reaction times