@article {Catharina Boon10.1212 / WNL。0000000000207685,作者= {Baayla迪米特里Catharina恩惠和悉尼Labuzan中卫彭和比利Matchett Kouri拿俄米和凯莉米亨克尔和基督教Lachner和欧文罗斯和Nilufer Ertekin-Taner和里基·e·卡特和坦尼斯j . Ferman和Ranjan这和丹尼斯·w·迪克森和尼尔Graff-Radford和梅丽莎·e·默里},title ={回顾性评价Neuropathologic代理的最小萎缩亚型相比Corticolimbic阿尔茨海默病亚型},elocation-id = {10.1212 / WNL。={2023}0000000000207685},年,doi = {10.1212 / WNL。出版商0000000000207685}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景:{\ textquoteright}年代老年痴呆症(广告)是神经病理学分首页为三个corticolimbic基于神经原纤维缠结的亚型分布在海马和联合皮层:边缘的,典型的,和海马爱惜。体内,第四个亚型,称为最小{\ textquotedblleft} {\ textquotedblright}萎缩,被确认使用结构磁共振成像。摘要目的:本研究的目的是确定一个neuropathologic neuroimaging-defined最小萎缩亚型的代理。方法:我们应用两种策略的佛罗里达解剖多民族(火焰)群组评价neuropathologic最小萎缩亚型的代理。在第一个策略中,我们选择广告例Braak IV混乱阶段,因为皮层纠结的相对缺乏参与相比Braak \ >第四。Braak第四例相比,三个亚型。在另一种策略,典型的广告是由大脑重量和分层的情况下有一个相对较高的脑重量(\ > 75)被定义为最小的萎缩。结果:Braak 4例(n = 37)与广告不同亚型(边缘主要(n = 174),典型的(n = 986),保留和海马(n = 187)广告)的至少有多年的教育(12年,中位数group-wise p \ < 0.001)和最高的脑重量(平均1140克,p = 0.002)。 Braak IV cases most resembled the limbic predominant cases owing to their high proportion of APOE ε4 carriers (75\%, p\<0.001), an amnestic syndrome (100\%, p\<0.001), as well as older age of cognitive symptom onset and death (median 79 and 85 years, respectively, p\<0.001). Only 5\% of Braak IV had amygdala predominant Lewy bodies (the lowest frequency observed, p=0.017), whereas 32\% had coexisting pathology of Lewy body disease which was greater than the other subtypes (p=0.005). Nearly half (47\%) of the Braak IV sample had coexisting limbic-predominant age-related TDP-43 encephalopathy neuropathologic change. Cases with a high brain weight (n=201) were less likely to have amygdala predominant Lewy bodies (14\%, p=0.006) and most likely to have Lewy body disease (31\%, p=0.042) compared to those with middle (n=455) and low brain weight (n=203).Discussion: The frequency of Lewy body disease was increased in both neuropathologic proxies of the minimal atrophy subtype. We hypothesize that Lewy body disease may underlie cognitive decline observed in minimal atrophy cases.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/08/14/WNL.0000000000207685}, eprint = {//www.ez-admanager.com/content/early/2023/08/14/WNL.0000000000207685.full.pdf}, journal = {Neurology} }