TY -的T1 -评价聚类的方法来定义不同的子组的偏头痛患者选择电针刺激治疗JF -神经学乔-神经病学SP - e699 LP - e709做- 10.1212 / WNL。首页0000000000207484六世- 101 - 7盟轨迹刘盟Shilan全非盟- Ling赵盟开元AU -延安,王盟——宇通张盟- Ziwen王盟以下太阳AU -李胡锦涛Y1 - 2023/08/15 UR - //www.ez-admanager.com/content/101/7/e699.abstract N2 -背景和目的本研究的目的是提出一种聚类方法确定偏头痛组和测试的临床实用性的方法通过提首页供预后信息电针刺激治疗选择。方法对参与者先兆型偏头痛(MWoA)被要求完成一个每日头痛日记,自我评定的抑郁和焦虑,生活质量调查问卷。全脑功能连接性(FCs)评估在静息状态功能磁共振成像(fMRI)。通过整合临床测量和功能磁共振成像数据,偏最小二乘的相关性和层次聚类分析被用来与MWoA集群参与者。多元模式分析应用来验证该子群的策略。一些参与者有8周电针刺激治疗,和响应率不同MWoA子组之间的比较。结果在研究1中,共有97名参与者(28.2±1.0岁,70名女性参与者)与MWoA和77名健康对照组(高碳钢)(26.8±0.1岁,61名女性参与者)为(数据集1),和2 MWoA子组被定义。子群1中的参与者有显著降低头痛频率(次/月的4.4±1.1)和显著提高抑郁症的评价(49.5±2.3)抑郁得分相比,参与小组2(7.0±0.6次/月和抑郁得分为43.4±1.2)。FCs的差异主要与杏仁核、丘脑、海马、海马旁区域。在研究2中,33个参与者MWoA(30.9±2.0岁,28岁女性参与者)和23个高碳钢(29.8±1.1岁,13女性参与者)为作为一个独立的数据集(dataset 2)。分类分析验证的有效性与MWoA 2-cluster解决方案的参与者数据集1和2。 In study 3, 58 participants with MWoA were willing to receive electroacupuncture treatment and were assigned to different subgroups. Participants in different subgroups exhibited different response rates (p = 0.03, OR CI 0.086–0.93) to electroacupuncture treatment (18% and 44% for subgroups 1 and 2, respectively).Discussion Our study proposed a novel clustering approach to define distinct MWoA subgroups, which could be useful for refining the diagnosis of participants with MWoA and guiding individualized strategies for pain prophylaxis and analgesia.AUC=area under the receiver operating characteristic curve; EF=emotional function; FC=functional connectivity; fMRI=functional MRI; HC=healthy control; MSQ=Migraine-Specific Quality-of-Life Questionnaire; MVPA=multivariate pattern analysis; MWoA=migraine without aura; NRS=numerical rating scale; PLSC=partial least squares correlation; ROI=region of interest; RP=role function–preventive; RR=role function–restrictive; SAS=self-rating anxiety scale; SDS=self-rating depression scale; SVM=support vector machine; VRS=variance ratio score ER -