PT -期刊文章盟Carin Northuis AU -伊丽莎白·贝尔盟帕梅拉Lutsey AU -克里斯汀米乔治盟——丽贝卡·f·戈特斯曼盟——汤姆·h·莫斯利盟——埃里克Whitsel盟——Kamakshi说TI -累计使用质子泵抑制剂和痴呆的风险:动脉粥样硬化的风险在社区研究援助- 10.1212 / WNL。0000000000207747 DP - 2023 8月09年TA -神经病首页学PG - 10.1212 / WNL。0000000000207747 4099 - http://n.首页neurology.org/content/early/2023/08/09/WNL.0000000000207747.short 4100 - //www.ez-admanager.com/content/early/2023/08/09/WNL.0000000000207747.full AB -背景。研究质子泵抑制剂(PPI)使用之间的关系和痴呆报告好坏参半的结果,不检查累积PPI使用的影响。我们评估当前和累积使用PPI和之间的关联事件发生痴呆的风险在社区动脉粥样硬化风险(ARIC Study.Methods)。这些分析使用参与者从一个以社区为基础的群体(ARIC)入学的时间(1987 - 89)到2017年。PPI的使用是通过视觉评估药物库存在诊所访问1(1987 - 89)到5(2011 - 13),每年报告研究电话(2006 - 2011)。本研究使用ARIC访问5作为基线,因为这是第一个访问的PPI使用很普遍。PPI使用了两种方法:目前使用访问5和持续时间的利用之前访问5(参观1到2011,接触类别:0天,1天- 2.8岁,2.8 - -4.4年,在4.4岁)。结果在访问事件痴呆5。Cox比例风险模型被使用,调整人口结构,use.Results合并病症和其他药物治疗。 A total of 5,712 dementia-free participants at visit 5 (mean age 75.4±5.1 years; 22% Black race; 58% female) were included in our analysis. The median follow-up was 5.5 years. Minimum cumulative PPI use was 112 days and maximum use was 20.3 years. There were 585 cases of incident dementia over median follow up time. Participants using PPIs at Visit 5 were not at a significantly higher risk of developing dementia during subsequent follow-up than those not using PPIs (Hazard Ratio (HR): 1.1 [95% Confidence Interval (CI): 0.9-1.3]). Those who used PPIs for >4.4 cumulative years prior to Visit 5 were at 33% higher risk of developing dementia during follow-up (HR: 1.3 [95%CI: 1.0-1.8]) than those reporting no use. Associations were not significant for lesser amounts of PPI use.Discussion. Future studies are needed to understand possible pathways between cumulative PPI use and the development of dementia.Classification of Evidence. This study provides Class III evidence that use of prescribed PPIs for > 4.4 years by individuals ages 45 years and older is associated with a higher incidence of newly diagnosed dementia.

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