@article {Cabreira10.1212 / WNL。0000000000207673,作者= {Veronica Cabreira,丹尼尔·费雷拉和Cl {\ '} udia甜瓜,琼娜Rebelo和杰西塔丰和拉奎尔Sousa Mafalda桑帕约},title ={儿童神经病学:Anti-Hu脑炎在一个青少年纵隔精原细胞瘤},elocation-id = {10.1212 / WNL。首页={2023}0000000000207673},年,doi = {10.1212 / WNL。出版商0000000000207673}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘= {Anti-Hu抗体与自身免疫综合征,主要边缘脑炎、脑脊髓炎和痛苦的感觉多神经首页病(Denny-Brown)。我们报告一例15岁男孩出现epilepsia partialis连续(EPC)发现右额叶中回大脑病变没有萎缩或侧参与。部分切除后,神经病理学显示神经元丢失、反应性胶质增生和astrocytosis以及血管周的单核炎症噬节类似拉斯穆森脑炎的渗透和特征。抗癫痫药物和手术不良反应促使进一步检查阳性血清anti-Hu抗体的识别和纵隔精原细胞瘤。免疫疗法包括皮质类固醇治疗的病人,血浆置换联合丙种球蛋白、硫唑嘌呤、利妥昔单抗和纵隔病变切除。然而,他继续体验EPC,精神运动障碍以及左轻偏瘫和构音障碍。鉴于临床进展未能应对免疫治疗和预防polytherapy、hemispherotomy未遂,没收自由实现。文献回顾发现,只有16例神经与儿童anti-Hu抗体相关的演示,确认EPC在这些情况下的罕见。 Thus, this report provides a new observation of germ cell mediastinal tumour associated with anti-Hu antibodies in children broadening the spectrum of anti-Hu{\textendash}associated neurologic disorder in children and highlighting the importance of considering antineuronal antibody testing in children presenting with EPC and brain lesions suggestive of Rasmussen encephalitis.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/08/01/WNL.0000000000207673}, eprint = {//www.ez-admanager.com/content/early/2023/08/01/WNL.0000000000207673.full.pdf}, journal = {Neurology} }