TY -的T1序列黑多巴胺能成像与路易小体轻度认知障碍,阿尔茨海默病,年龄组的JF -神经学乔-神经学做- 10.1212 / WNL。首页0000000000207621 SP - 10.1212 / WNL。0000000000207621 AU - Rory Durcan盟吉玛罗伯茨盟——富勒姆·汉密尔顿盟——保罗·C多纳吉AU -豪金盟肖恩·J Colloby AU -露易丝米艾伦盟乔治-迈克尔Firbank AU -莎拉·罗莉AU - S Petrides盟——吉姆·J·劳埃德盟——约翰·保罗·泰勒盟——约翰·t·奥布莱恩盟——艾伦·J·托马斯Y1 - 2023/07/31 UR - //www.ez-admanager.com/content/early/2023/07/31/WNL.0000000000207621.abstract N2 -背景和目标进步黑通路变性发生在路易体痴呆患者(下文)。首页我们的目的是调查是否重复123年[我]-FP-CIT SPECT可以识别进步多巴胺损失轻度认知障碍(MCI)和路易小体(MCI-LB)。方法MCI-LB和MCI患者由于阿尔茨海默氏症(MCI-AD)进行了全面的临床评估,123年[我]-FP-CIT SPECT在基线和年度评审时,心脏123 i-mibg和基线。混合效应模型被用来研究变化在123年[我]-FP-CIT特定约束力的比率(SBR)纹状体为每个诊断组与对照组。定量的时间间隔的发展异常123[我]-FP-CIT SPECT和可能MCI-LB集团可能是确定的时间这些团体达成纹状体吸收两个标准差低于aged-matched控制。测试重新测试变化评估使用基线和重复扫描控制。结果我们招募了20个人MCI-AD 11可能MCI-LB, 25可能MCI-LB和29岁年龄组。基线和最终的图像之间的平均时间是1.6年(范围SD = 0.9, 1.0, 4.3)。每年估计控制的SBR为0.23变化(95%置信区间CI: -0.07 - 0.53), -0.09 MCI-AD(-0.55 - 0.36), -0.50(-1.03 - 0.04)可能MCI-LB和-0.48(-0.89 - -0.06)可能MCI-LB。 The median annual percentage change in SBR in MCI-LB was -5.6% (95% CI: -8.2% to -2.9%); 2.1% (-3.5% to 8.0%) for MCI-AD. The extrapolated time for a normal scan to become abnormal was 6 years. Controls and MCI-AD showed no significant change in dopaminergic binding over time. The mean test-retest variation in controls was 12% (SD 5.5%), which cautions against over-interpretation of small changes on repeat scanning.Discussion Progressive dopaminergic loss in the striatum is detectable using 123[I]-FP-CIT SPECT in MCI-LB at a group level. In clinical practice, individual change in striatal 123[I]-FP-CIT uptake appears to be of limited diagnostic value due to high test-retest variation.Classification of Evidence This study provides Class II evidence that longitudinal declines in striatal uptake measured via 123[I]-FP-CIT SPECT are associated with mild cognitive impairment (MCI) due to Lewy body disease but not MCI due to Alzheimer disease. ER -