TY -的T1 -协会认知能力下降的神经精神症状资料帕金森疾病和轻度认知障碍患者JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207623 SP - 10.1212 / WNL。0000000000207623 AU -年轻李盟盟Mincheol公园- Seong Ho宋盟Kyoungwon Baik盟——SUNGWOO康盟——所以胡恩Yoon AU -汉级Na盟年轻孙h . AU -菲尔Hyu李Y1 - 2023/07/31 UR - //www.ez-admanager.com/content/early/2023/07/31/WNL.0000000000207623.abstract N2 -首页背景和目的:神经精神症状(NPS)与认知能力下降密切相关的帕金森病(PD)患者。我们调查的NPS与痴呆的风险PD患有轻度认知障碍(PD-MCI)。方法:我们回顾性评估338例PD-MCI从一个三级医院,接受神经心理学测试和神经精神病学的库存(NPI)问卷。我们进行了因素分析12 NPI一分为二的存在的症状,收益率三个NPI因素:因素1,情绪症状;因子2,hyperactivity-related症状;因子3,精神病症状。因子分析NPI症状的严重性还发现了类似的NPI的因素。NPI的神经精神相关因素评估使用一般线性模型的认知测试。随后,我们评估了风险比(人力资源)的NPI因素转换为痴呆。Results: A higher prevalence factor 1 score was associated with lower scores in the verbal memory (β = -0.15; 95% confidence interval [CI] = -0.24 – -0.06; p = 0.001) and executive domains (β = -0.16; 95% CI = -0.28 – -0.04; p = 0.007), whereas higher severity factor 2 scores were associated with lower scores in the naming (β = -0.16; 95% CI = -0.28 – -0.03; p = 0.012), visuospatial (β = -0.24; 95% CI = -0.41 – -0.07; p = 0.005), and verbal memory domains (β = -0.15; 95% CI = -0.24 – -0.05; p = 0.005). A higher severity factor 3 score was associated with lower scores in the visuospatial domain (β = -0.25; 95% CI = -0.46 – -0.07; p = 0.007). Cox regression models demonstrated that the risk of dementia was increased in those with higher prevalence factor 1 (HR = 1.48, 95% CI = 1.17 – 1.88, p = 0.001) and factor 2 scores (HR = 1.27, 95% CI = 1.07 – 1.51, p = 0.007) and severity factor 3 score (HR = 1.52, 95% CI = 1.29 – 1.80, p < 0.001) after adjusting for age, sex, education, disease duration, scores for cognition and parkinsonism, and levodopa equivalent dose.Discussion: This study demonstrated that a higher burden of NPS is associated with dementia conversion in patients with PD-MCI. ER -