TY - T1的脉络丛卷与血清生物标志物,协会的临床特征和疾病严重程度患者的额颞叶大叶性变性频谱JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207600 SP - 10.1212 / WNL。0000000000207600 AU -马蒂娜Assogna盟Enrico Premi AU -斯特凡诺Gazzina盟Nicholas J阿什顿-阿尔贝托Benussi盟盟- Henrik Zetterberg盟Kaj Blennow AU -罗伯托·Gasparotti盟-亚历山德罗Padovani盟伊桑·Tadayon AU -萨拉Romanella盟会Sprugnoli盟盟Alvaro pascual - leone -弗朗西斯科·迪洛伦佐盟Giacomo科赫AU -芭芭拉Borroni盟埃米利亚诺·Santarnecchi Y1 - 2023/07/27 UR - //www.ez-admanager.com/content/early/2023/07/26/WNL.0000000000207600.abstract N2 -背景和目标:脉络丛(ChP)正成为一个关键的大脑结构在神经退行性疾病的病理生理学。首页在这观察研究我们调查ChP群体的额颞叶体积大叶性变性(FTLD)光谱患者探索可能ChP体积之间的关系和其他特定疾病生物标志物。方法:参与者包括病人会议可能综合症的临床标准FTLD频谱。结构大脑核磁共振成像,血清神经丝光(NfL)和血清phosphorylated-Tau181 (p-Tau181),认知和行为数据收集。MRI ChP卷获得从一个特别的细分模型基于高斯混合模型(GMM)算法。结果:三百年和16例在FTLD光谱包含在这项研究中,特别是135例诊断为行为变异额颞叶痴呆(bvFTD), 75年原发性进行性失语(PPA), 46进行性核上的麻痹(PSP), 60 corticobasal综合症(CBS)。此外,82年的同龄健康受试者招募控制(HC)。ChP成交量明显增大FTLD患者与HC相比,在临床亚型。此外,我们发现了一个显著差异在ChP HC与病人对疾病严重程度分层基于CDRplus NACC FTLD,包括患者在疾病的早期阶段。有趣的是,ChP体积与血清NfL,认知/行为赤字,以及皮质萎缩的模式。 Finally, ChP volume seemed to discriminate HC from FTLD patients better than other previously identified brain structure volumes.Discussion: Considering the clinical, pathological, and genetic heterogeneity of the disease, ChP could represent a potential biomarker across the FTLD spectrum, especially at the early stage of disease. Further longitudinal studies are needed to establish its role in disease onset and progression.Classification of Evidence: This study provides Class III evidence that choroid plexus volume, as measured on MRI scan, can assist in differentiating patients with FTLD from healthy controls, and in characterizing disease severity. ER -