RT期刊文章SR电子T1协会限制皮层下灰质和白质病变患者的左半球中风摩根富林明神经失用症的赤字乔神经病学FD Lippincott Williams &威尔金斯10.1212 SP / WNL。首页0000000000207598 10.1212 / WNL。0000000000207598 A1克劳迪娅·c·施密特A1伊丽莎白A1尼娜n i s阿基里斯A1 Katharina Bolte拍摄Kleineberg A1莫妮卡k级A1娜塔莉城堡A1 Gereon r·芬克A1彼得·h·维斯年2023 UL //www.ez-admanager.com/content/early/2023/07/18/WNL.0000000000207598.abstract A首页B背景和目标:失用症通常被归因于左半球病变的皮质fronto-temporo-parietal实践网络或白质病变引起皮质节点之间的断开连接。相比之下,皮层下灰质病变的贡献,即。、基底节、丘脑、失用症的赤字仍存在争议。在这里,我们调查是否这些皮层下灰质结构(即受损。、尾状核、壳核、苍白球、丘脑)或邻近白质束与失用症的赤字。方法:我们确定不同皮层下病变患者,没有失用症的大型回顾展样本sub-acute左脑缺血性中风患者(n = 194)。皮层下结构的测试(尾状核、壳核、苍白球、丘脑和邻近白质束),当损伤,导致失用症的赤字,我们统计比较的比例进行体素内皮层下灰质和白质结构之间non-apraxic和失用症的病人。结果:194名中风患者的筛查,39岁(年龄中位数= 65年,射程30−82年;中位数时间中风后的失用症评估= 7天,范围1−44天)病变局限于皮质下区域(灰色和白色物质)。11个病人显示失用症的赤字当模仿手势或上演对象使用。哪些地区统计损伤比较(控制病变大小)显示比例更大的损害(尾状核病变负载)的失用症的中风患者(平均差= 6.9%,95%可信区间(CI) 0.4 - -13.3, P = 0.038,ηp2 = 0.11)。 In contrast, apraxic patients had lower lesion load in the globus pallidus (mean difference = 9.9%, 95% CI 0.1–19.8, P = 0.048, ηp2 = 0.10), while the lesion load in other subcortical structures (putamen, thalamus, adjacent white matter tracts) did not differ significantly between the apraxic and non-apraxic patients.Discussion: These findings provide new insights into the subcortical anatomy of apraxia following left hemisphere stroke, suggesting a specific contribution of caudate nucleus lesions to apraxic deficits.