@article {Schmidt10.1212 / WNL。0000000000207598,作者={克劳迪娅·c·施密特和伊丽莎白和尼娜n i s阿基里斯和卡特Bolte拍摄Kleineberg莫妮卡k·里希特和娜塔莉城堡Gereon r·芬克和彼得·h·维斯},title ={协会限制皮层下灰质和白质病变患者的失用症的赤字左半球中风},elocation-id = {10.1212 / WNL。={2023}0000000000207598},年,doi = {10.1212 / WNL。出版商0000000000207598}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标:失用症通常被归因于左半球病变的皮质fronto-temporo-p首页arietal实践网络或白质病变引起皮质节点之间的断开连接。相比之下,皮层下灰质病变的贡献,即。、基底节、丘脑、失用症的赤字仍存在争议。在这里,我们调查是否这些皮层下灰质结构(即受损。、尾状核、壳核、苍白球、丘脑)或邻近白质束与失用症的赤字。方法:我们确定不同皮层下病变患者,没有失用症的大型回顾展样本sub-acute左脑缺血性中风患者(n = 194)。皮层下结构的测试(尾状核、壳核、苍白球、丘脑和邻近白质束),当损伤,导致失用症的赤字,我们统计比较的比例进行体素内皮层下灰质和白质结构之间non-apraxic和失用症的病人。结果:194名中风患者的筛查,39岁(年龄中位数= 65年,范围30 - 82年;中位数时间中风后的失用症评估= 7天,美国天)有病变范围局限于皮质下区域(灰色和白色物质)。11个病人显示失用症的赤字当模仿手势或上演对象使用。 Region-wise statistical lesion comparison (controlled for lesion size) revealed a more significant proportion of damage ({\textquoteleft}lesion load{\textquoteright}) in the caudate nucleus in apraxic stroke patients (mean difference = 6.9\%, 95\% confidence interval [CI] 0.4{\textendash}13.3, P = 0.038, ηp2 = 0.11). In contrast, apraxic patients had lower lesion load in the globus pallidus (mean difference = 9.9\%, 95\% CI 0.1{\textendash}19.8, P = 0.048, ηp2 = 0.10), while the lesion load in other subcortical structures (putamen, thalamus, adjacent white matter tracts) did not differ significantly between the apraxic and non-apraxic patients.Discussion: These findings provide new insights into the subcortical anatomy of apraxia following left hemisphere stroke, suggesting a specific contribution of caudate nucleus lesions to apraxic deficits.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/07/18/WNL.0000000000207598}, eprint = {//www.ez-admanager.com/content/early/2023/07/18/WNL.0000000000207598.full.pdf}, journal = {Neurology} }