% 0期刊文章% Katharina Seystahl %尼古拉斯Martinez-Majander %一个亚历山大·萨勒诺%莫兰Beyeler % Hebun Erdur %一个Joao Pedro Marto %基督教Hametner % Marialuisa Zedde %亚历桑德罗·Pezzini % Ronen列克%一个蒋禄卡Costamagna缬草Altersberger % %一个米格尔Serodio % Ludovica阶段%罗萨里奥Pascarella % Andrea辛尼%一个亚尼克Bejot劳拉Mannismaki % %一个西蒙·荣格% Henrik Gensicke % Visnja Padjen %一个彼得·A . Ringleb %一个基督徒的帕特里克•米歇尔•诺尔特% Mirjam R Heldner % %一个萨米Curtze斯蒂芬·T·Engelter % % Susanne韦格纳迈克尔·韦勒% % T静脉溶栓有或没有血管内治疗疑似缺血性中风患者的颅内肿瘤% D R 10.1212 / WNL 2023%。0000000000207624 % J首页神经病学% P 10.1212 / WNL。0000000000207624 X %的背景和目的:静脉溶栓(溶)疑似缺血性中风患者的颅内肿瘤标示外。然而,颅内出血的风险数据(我)是稀缺。方法:在欧洲多中心基于注册分析缺血性中风患者的溶栓(TRISP)合作,我们评估的频率和致命的症状我诊断后疑似缺血性中风患者的颅内肿瘤通过描述性统计和分析协会的临床和影像特征的二元逻辑回归。出血症状的定义是基于欧洲合作的临床标准急性Stroke-II试验包括在任何网站在颅骨成像和并发出血的临床恶化。结果:筛选来自14个中心的21289名患者的数据,我们确定了105名患者接受诊断,其中29个病人(28%)和额外的血管内治疗,怀疑,即成像,或颅内肿瘤的组织学证实诊断。104 CT或MRI诊断可用后,患者症状和致命我观察在9和4名患者(9%和4%)。82名疑似或确诊脑膜瘤患者,症状和致命我发生在6和3名患者(7%和4%)。患者在18个intra-axial疑似或确诊主要或次要脑部肿瘤,有一个非致命的症状我(6%)。的四个肿瘤患者垂体区域,两个病人(50%)有出血症状包括一个致命的我(25%)。 Tumor size was not associated with occurrence of symptomatic ICH (Odds ratio 2.8, 95% CI 0.3-24.8, p=0.34).Discussion:In our dataset from routine clinical care, we provide insights on the safety of IVT for suspected ischemic stroke in patients with intracranial tumors, a population that is commonly withheld thrombolysis in clinical practice and prospective trials. Except for a potential high risk of symptomatic ICH after IVT in patients with tumors of the pituitary region, frequencies of symptomatic ICH in patients with intracranial tumors in our cohort appear to be in the upper range of rates observed in previous studies within the TRISP cooperation. These results may guide individual treatment decisions in patients with acute stroke and intracranial tumors with potential benefit of IVT. %U //www.ez-admanager.com/content/neurology/early/2023/07/18/WNL.0000000000207624.full.pdf