% 0期刊文章%安娜> %一个尼古拉斯·j·阿什顿% Henrik Zetterberg % Kaj Blennow %一个安娜Zettergren %乔尔Simren % Tobias Skillback %一个萨拉·夏姆斯% Alejandra Machado %一个迈克尔肖勒埃里克·韦斯特曼% %英格玛·斯% Silke Kern % T慢性肾病协会与等离子体NfL和其他生物标记的神经退化% B H70出生队列研究在哥德堡% D R 10.1212 / WNL 2023%。0000000000207419 % J首页神经病学% P e277-e288 % V 101% N 3% X背景和目标的研究将慢性肾脏疾病(CKD)与神经退化。这项研究调查了肾功能之间的关系,血液、脑脊液、结构性大脑MRI的标记神经退行性变的一个示例包括患者和慢性肾病。方法从哥德堡H70出生队列研究参与者,与等离子体光神经丝(P-NfL)的数据,估计肾小球滤过率(eGFR)和结构包括脑部核磁共振。参与者被邀请也收集的脑脊液。本研究的主要终点是确定任何CKD和P-NfL之间的联系。二次端点包括横断面CKD之间的关联,表皮生长因子受体、神经退行性病变和CSF-derived MRI-derived标记和阿尔茨海默病(AD)病理(MRI:皮质厚度,海马体积,侧脑室体积,体积和白质病变;CSF:β-amyloid (Aβ)42、Aβ42/40 Aβ42 / p-tau t-tau p-tau, NfL)。参与者P-NfL和表皮生长因子受体eGFR在基线审查,5.5(5.3 - -6.1)年(中位数;位差)后的第一次访问,P-NfL级别事件的预测价值CKD估计纵向,使用Cox比例风险模型。结果包括了744名参与者,668没有CKD(71岁(70 - 71)年,50%的男性)与慢性肾病和76年(71岁(70 - 71)年,39%的男性)。生物标志物的CSF分析了313名参与者。 A total of 558 individuals returned for a re-examination of eGFR (75% response rate, age 76 [76; 77] years, 48% males, 76 new cases of CKD). Participants with CKD had higher P-NfL levels than those with normal kidney function (median; 18.8 vs 14.1 pg/mL, p < 0.001), while MRI and CSF markers were similar between the groups. P-NfL was independently associated with CKD after adjustment for confounding variables, including hypertension and diabetes (OR; 3.231, p < 0.001), in a logistic regression model. eGFR and CSF Aβ 42/40: R = 0.23, p = 0.004 correlated in participants with Aβ42 pathology. P-NfL levels in the highest quartile were associated with incident CKD at follow-up (HR; 2.39 [1.21: 4.72]).Discussion In a community-based cohort of 70-year olds, P-NfL was associated with both prevalent and incident CKD, while CSF and/or imaging measures did not differ by CKD status. Participants with CKD and dementia presented similar levels of P-NfL.Aβ=β-amyloid; AD=Alzheimer disease; BMI=body mass index; CDR=clinical dementia rating; CKD=chronic kidney disease; COPD=chronic obstructive pulmonary disease; CRP=C-reactive protein; eGFR=estimated glomerular filtration rate; HDL=high-density lipoprotein; LDL=low-density lipoprotein; LP=lumbar puncture; NfL=neurofilament light protein; P=plasma; p=phosphorylated; t=total %U //www.ez-admanager.com/content/neurology/101/3/e277.full.pdf