TY -的T1 -机械血栓切除术对于大型缺血性中风:系统回顾和荟萃分析JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207536 SP - 10.1212 / WNL。0000000000207536 AU -气李盟穆罕默德Abdalkader AU - James e . Siegler盟Shadi Yaghi AU - Amrou Sarraj AU -布鲁斯·c·v·坎贝尔盟阿尔伯特·j·Yoo AU -奥萨马o . Zaidat盟Johannes Kaesmacher AU -深Pujara盟劳尔G Nogueira Lei李盟盟- Jeffrey l .节省盟-秦汉盟易戴盟-红飞唱非盟-杨Qingwu盟Thanh n .阮盟Zhongming邱Y1 - 2023/06/05 UR - //www.ez-admanager.com/content/early/2023/06/05/WNL.0000000000207536.abstract N2 -背景和目标有越来越多的证据表明血管内血栓切除术(EVT)患者大缺血性梗塞核心和大血管闭塞。首页本研究的目的是比较EVT和医疗管理的有效性和安全性(毫米)通过系统回顾和荟萃分析的观察性研究和随机对照试验(相关的)。方法我们搜索PubMed、Embase Cochrane图书馆、科学和Web数据库获取文章相关机械血栓切除术对于大型缺血性核心从开始到2月10日,2023年。主要结果是独立的移动(改良Rankin规模(夫人)0 - 3)。效应值被计算为风险率(RR)和随机效应或固定效应模型。文章的质量是评估通过Cochrane风险评估工具和Newcastle-Ottawa规模。本研究在普洛斯彼罗注册(CRD42023396232)。结果共有5395篇文章通过搜索和获得的文章不符合入选标准审查被排除在外的标题、摘要和全文。最后,3相关和10个群组研究符合入选标准。The RCT analysis showed that EVT improved the 90-day functional outcomes of patients with large ischemic core with high-quality evidence, including independent ambulation (mRS 0-3: RR 1.78, 95% CI 1.28-2.48, P < 0.001) and functional independence (mRS 0-2: RR 2.59, 95% CI 1.89-3.57, P < 0.001), but without significantly increasing the risk of symptomatic intracranial hemorrhage (sICH: RR 1.83, 95% CI: 0.95-3.55, P = 0.07) or early mortality (RR 0.95, 95% CI 0.78-1.16, P = 0.61). Analysis of the cohort studies showed that EVT improved functional outcomes of patients without an increase in the incidence in sICH.Conclusion This systematic review and meta-analysis indicates that in patients with large vessel occlusion stroke with a large ischemic core, EVT was associated with improved functional outcomes over medical management without increasing sICH risk. Results of ongoing RCTs may provide further insight in this patient population. ER -