PT -期刊文章盟会Fadda AU -阿隆索Cardenas de la Parra盟盟茱莉亚O’mahony -帕特里克水域盟- e·安叶盟-阿米特酒吧或非盟-露丝安上盟Sridar Narayanan AU -道格拉斯·阿诺德AU - d·路易斯·柯林斯盟-布伦达Banwell ED - TI -偏离规范儿童全脑灰质和深度增长MOGAD,女士,单相血清反应阴性的髓鞘脱失援助- 10.1212 / WNL。0000000000207429 DP - 2023年5月31日TA -神经病首页学PG - 10.1212 / WNL。0000000000207429 4099 - http://n.首页neurology.org/content/early/2023/05/31/WNL.0000000000207429.short 4100 - //www.ez-admanager.com/content/early/2023/05/31/WNL.0000000000207429.full AB -背景和目的:小儿获得相关的中枢神经系统脱髓鞘与抗体针对髓少突细胞糖蛋白(MOG-antibody相关疾病,MOGAD)发生单相或疾病复发和变量,但往往广泛T2损伤大脑。成熟期间MOGAD对大脑发育的影响是未知的。我们量化的影响小儿MOGAD对大脑的增长轨迹,并与同期年龄的增长轨迹——sex-matched健康儿童和儿童多发性硬化症(MS,慢性复发疾病已知影响大脑发育)和单相血清反应阴性的髓鞘脱失。方法:我们在事件注册包括孩子袭击的前瞻性纵向加拿大儿科脱髓鞘疾病研究招募了三大招生网站,接受研究的大脑核磁共振扫描,检测血清MOG-IgG抗体。MOG-IgG被诊断出患有MOGAD儿童血清反应阳性的。每2017年麦当劳女士被诊断标准。单相血清反应阴性的脱髓鞘与任何临床和MRI证实儿童复发性脱髓鞘的证据,和消极MOG-IgG和aquaporin-4-IgG。整个区域脑容量是通过对称非线性计算注册模板。我们计算年龄,sex-normalized z得分813年脑容量使用规范的数据集的大脑核磁共振扫描得到正常发育的孩子,并使用混合效应模型来评估潜在的偏差从大脑的增长轨迹。结果:我们的46 MOGAD患儿的脑容量评估,与女士26日,51与单相血清反应阴性的脱髓鞘综合症。Children with MOGAD exhibited delayed (p<0.001) age- and sex-expected growth of thalamus, caudate and globus pallidus, normalized for the whole brain volume. Divergence from expected growth was particularly pronounced in the first year post-onset, and was detected even in children with monophasic MOGAD. Thalamic volume abnormalities were less pronounced in children with MOGAD compared to children with MS.Interpretation/discussion: The onset of MOGAD during childhood adversely affects the expected trajectory of growth of deep gray matter structures, with accelerated changes in the months following an acute attack. Further studies are required to better determine the relative impact of monophasic versus relapsing MOGAD, and whether relapsing MOGAD with attacks isolated to the optic nerves or spinal cord impacts brain volume over time.