@article {Change2409作者={琳达Chang和梅根·c·瑞恩尹华军梁和鑫张埃里克·坎宁安和贾斯汀王埃莉诺·威尔逊和爱德华·h·Herskovits Shyamasundaran Kottilil和托马斯·m·恩斯特},title ={大脑活动模式的变化在工作记忆任务中有Post-COVID条件和持续的神经精神症状的人},体积={100}={23},页面= {e2409——e2423} = {2023}, doi = {10.1212 / WNL。出版商0000000000207309}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标Post-COVID条件(PCC)是普遍的,往往也是涉及神经精神症状首页。本研究旨在利用血氧水平依赖{\ textendash} fMRI (BOLD-fMRI)与PCC评估参与者是否有异常的大脑活动在工作记忆(WM)和异常的大脑激活能否预测认知能力,运动机能,或精神症状。方法与PCC参与者记录的冠状病毒疾病2019 (COVID-19)入学前至少6周。健康控制参与者没有之前的历史COVID-19和负面测试严重急性呼吸系统综合症冠状病毒2。参与者评估使用3 NIH工具箱(NIHTB)电池认知(NIHTB-CB)、情感(NIHTB-EB)和运动机能(NIHTB-MB)和选择测试Patient-Reported结果测量信息系统(PROMIS)。每个在3 t BOLD-fMRI WM (n - back)任务期间增加注意力/ WM负载。结果一百六十九名参与者筛选;50实现研究标准和完成这个横断面队列研究和可用的数据集。29与PCC参与者被诊断出患有COVID-19 242 {\ textpm} 156天前;他们有相似的年龄(42 {\ textpm} 12 vs 41 {\ textpm} 12年),性别比例(65 \ % vs 57 \ %),种族/民族分布,用手习惯,教育,和社会经济地位,21未感染的健康对照组。尽管内存的高患病率(79 \ %)和浓度(93 \ %)抱怨,PCC组类似的性能在NIHTB-CB控制。然而,参与者与PCC大脑活动超过了控制整个网络(错误发现率{\ textendash}纠正p = 0.003,达峰时间= 4.17),以更大的激活在正确的额上回(p = 0.009,科恩d = 0.81, 95 \ % CI 0.15 {\ textendash} 1.46)但较小的失活在默认模式区域(d = 1.03, p = 0.001 95 \ % CI 0.61 {\ textendash} 1.99)。 Compared with controls, participants with PCC also had poorer dexterity and endurance on the NIHTB-MB, higher T scores for negative affect and perceived stress, but lower T scores for psychological well-being on the NIHTB-EB, as well as more pain symptoms and poorer mental and physical health on measures from the PROMIS. Greater brain activation predicted poorer scores on measures that were abnormal on the NIHTB-EB.Discussion Participants with PCC and neuropsychiatric symptoms demonstrated compensatory neural processes with greater usage of alternate brain regions, and reorganized networks, to maintain normal performance during WM tasks. BOLD-fMRI was sensitive for detecting brain abnormalities that correlated with various quantitative neuropsychiatric symptoms.AD=Alzheimer disease; BOLD-fMRI=blood oxygenation level{\textendash}dependent fMRI; COVID-19=coronavirus disease 2019; DMN=default mode network; FDR=false discovery rate; ISP=Index of Social Position; NIHTB=NIH-Toolbox Battery; NIHTB-CB=NIHTB for Cognition Battery; NIHTB-EB=NIHTB for Emotion Battery; NIHTB-TB=NIHTB for Motor Function Battery; PCC=post-COVID condition; PCG=posterior cingulate gyrus; PROMIS=Patient-Reported Outcomes Measurement Information System; SARS-CoV-2=severe acute respiratory syndrome coronavirus 2; SFG=superior frontal gyrus; SPM=Statistical Parametric Mapping; TE=echo time; TI=inversion time; TR=repetition time; WM=working memory}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/100/23/e2409}, eprint = {//www.ez-admanager.com/content/100/23/e2409.full.pdf}, journal = {Neurology} }