@article {Dittrich10.1212 / WNL。0000000000207419,作者={安娜> Nicholas J阿什顿和Henrik Zetterberg Kaj Blennow和安娜Zettergren乔尔Simr {} \ ' e n和Tobias Skillb {\“} ck和莎拉Shams Alejandra Machado和埃里克·韦斯特曼和迈克尔舒马赫{\ " o}会和英格玛·斯库和Silke Kern}, title ={慢性肾病协会与等离子体NfL和其他生物标记的神经退化:H70出生队列研究哥德堡},elocation-id = {10.1212 / WNL。={2023}0000000000207419},年,doi = {10.1212 / WNL。出版商0000000000207419}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目的:研究副慢性肾脏疾病(CKD)与神经退化。首页本研究调查了肾功能的关系,血液、脑脊液(CSF)和结构大脑核磁共振神经退化的标志,在一个没有CKD的示例包括个人和。方法:参与者从哥德堡H70出生队列研究中,数据在plasma-neurofilament光(P-NfL),估计肾小球滤过率(eGFR)和结构包括脑部核磁共振。参与者被邀请也CSF收集。本研究的主要终点是确定任何CKD和P-NfL之间的联系。二次端点包括横断面CKD之间的关联,eGFR和脑脊液(CSF)和MRI-derived标记神经退化和{\ textquoteright}年代老年痴呆症(广告)病理(MRI:皮质厚度,海马体积,侧脑室体积,白质病变体积;CSF:β-amyloid (Aβ)42、Aβ42/40 Aβ42 / p-tau t-tau p-tau, NfL)。参与者P-NfL和表皮生长因子受体eGFR在基线审查,5.5 (5.3;6.1)年(中位数; IQR) after the first visit, and the predictive value of P-NfL levels on incident CKD was estimated longitudinally, using a Cox proportional hazards model.Results: We included 744 participants, 668 without CKD (Age 71 (70; 71) years, 50\% males) and 76 with CKD (age 71 (70;71) years, 39\% males). Biomarkers from cerebrospinal fluid (CSF) were analysed in 313 participants. 558 individuals returned for a re-examination of eGFR (75\% response rate, age 76 (76; 77), 48\% males, 76 new cases of CKD). Participants with CKD had higher P-NfL levels than those with normal kidney function (median; 18.8 versus 14.0 pg/mL, p\<0.001), while MRI and CSF markers were similar between the groups. P-NfL was independently associated with CKD after adjustment for confounding variables, including hypertension and diabetes (OR; 3.231, p\<0.001), in a logistic regression model. eGFR, and CSF Aβ 42/40: R=0.23, p=0.004 correlated in participants with Aβ42 pathology. P-NfL levels in the highest quartile were associated with incident CKD at follow-up (HR; 2.08 (1.14: 4.50)).Discussion: In a community-based cohort of 70-year olds, P-NfL was associated with both prevalent and incident CKD, while CSF and/or imaging measures did not differ by CKD status. Participants with CKD and dementia presented similar levels of P-NfL.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/05/24/WNL.0000000000207419}, eprint = {//www.ez-admanager.com/content/early/2023/05/24/WNL.0000000000207419.full.pdf}, journal = {Neurology} }