PT -期刊文章盟Linbo王盟- Cheng周盟魏张盟张敏鸣AU -程魏盟剑锋冯TI -大脑皮层和皮层下组织协会临床进展和液体生物标志物在帕金森病的患者援助- 10.1212 / WNL。0000000000207408 DP - 2023年5月18日TA -神经病首页学PG - 10.1212 / WNL。0000000000207408 4099 - http://n.首页neurology.org/content/early/2023/05/18/WNL.0000000000207408.short 4100 - //www.ez-admanager.com/content/early/2023/05/18/WNL.0000000000207408.full AB -背景和目标意味着扩散系数(MD)的扩散磁共振成像(dMRI)已经被用来测量大脑皮层和皮层下微观结构属性。本研究调查的关系皮层和皮层下医学临床进展和液体生物标志物在帕金森病(PD)。方法这纵向研究使用数据从帕金森进展标记倡议(PPMI)收集从4月,2011年7月,2022年。临床症状进行评估与MDS-UPDRS和MoCA分数。临床评估随访5年。线性mixed-effects (LME)模型进行检验医学协会和年度的临床评分的变化。偏相关分析进行了检查协会医学和流体生物标志物水平。结果共有174例PD患者(61.9±9.7岁,63%的男性)和基线dMRI包括至少两年临床随访。LME三个模型的结果显示显著的MD值之间的联系,主要在皮质下区域,颞叶、枕叶和额叶,年增长率变化的临床评分(MDS-UPDRS-Part-I、标准化β比; 2.35; MDS-UPDRS-Part-II, standardized β > 2.34; PIGD score, standardized β > 2.47; MoCA, standardized β < -2.42; all P < 0.05, FDR corrected). In addition, MD was associated with the levels of neurofilament light chain (NfL) in serum (r > 0.22) and α-synuclein (right putamen r = 0.31), Amyloid-β 1 to 42 (Aβ42) (left hippocampus r = -0.30), phosphorylated tau at 181 threonine position (P-tau) (r > 0.26) and total tau (T-tau) (r > 0.23) in cerebrospinal fluid (CSF) at baseline (all P < 0.05, FDR corrected). Furthermore, the β coefficients derived from MD and annual rate of changes in clinical score recapitulated the spatial distribution of dopamine (DAT, D1 and D2), glutamate (mGluR5 and NMDA), serotonin (5-HT1a and 5-HT2a), cannabinoid (CB1) and GABAneurotransmitter receptors/transporters (P < 0.05, FDR corrected) derived from positron emission tomography scans in the brain of healthy volunteers.Discussion In this cohort study, cortical and subcortical MD values at baseline were associated with clinical progression and baseline fluid biomarkers, suggesting microstructural properties could be useful for stratification of patients with fast clinical progression.

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