TY -的T1β-Amyloid负载宠物沿着连续路易体痴呆的JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207393 SP - 10.1212 / WNL。0000000000207393 AU -帕特丽夏Diaz-Galvan盟斯科特Przybelski AU - Timothy G Lesnick盟克里斯托弗·G Schwarz AU -马修·L Senjem AU Jeffrey L Gunter AU -克利福德·r·杰克盟Hoon-Ki保罗分盟Manoj Jain AU -东寺Miyagawa盟利亚K Forsberg AU -朱莉一个字段盟Rodolfo Savica AU -乔纳森Graff-Radford AU -大卫·t·琼斯盟-雨果·博塔AU -埃里克·K·圣路易斯AU -大卫·S Knopman盟Vijay K Ramanan AU -欧文罗斯盟-尼尔Graff-Radford AU -格里高利节非盟-丹尼斯·w·迪克森盟坦尼斯j . Ferman AU -罗纳德·C彼得森AU - Val j·劳盟布拉德·F Boeve AU - Kejal Kantarci Y1 - 2023/05/18 UR - //www.ez-admanager.com/content/early/2023/05/18/WNL.0000000000207393.abstract N2 -背景:Amyloid-β斑块可以共现Lewy-related病理学在路易体痴呆患者(下文),但Amyloid-β负载在下文的前驱的阶段仍然需要阐明。首页我们调查amyloid-β负载宠物在下文连续体,从孤立的REM睡眠行为障碍的早期前驱期(iRBD)阶段的轻度认知障碍与路易小体(MCI-LB),最后下文。方法:我们进行了横断面研究患者诊断为iRBD, MCI-LB或下文从梅奥诊所阿尔茨海默病研究中心。Amyloid-β水平衡量匹兹堡化合物B(加以宠物和全球标准皮质吸收价值比率(SUVr)计算。全球皮质加以SUVr值从每个临床组比较,没有个人的认知(铜;n = 100)使用ANCOVA平衡在年龄和性别。我们使用多元线性回归测试交互学习的影响性和APOEε4地位加以SUVr下文连续。结果:162名患者,16 iRBD, 64年MCI-LB,和82年有下文。与铜相比,全球皮质加以SUVr高下文(p & lt;0.001)和MCI-LB (p = 0.012)。下文组包括amyloid-β阳性患者的比例最高(60%),其次是MCI-LB (41%)、iRBD(25%),最后是铜(19%)。 Global cortical PiB SUVr was higher in APOE ε4 carriers compared to APOE ε4 non-carriers in MCI-LB (p<0.001) and DLB groups (p=0.049). Women had higher PiB SUVr with older age compared to men across the DLB continuum (βeta estimate=0.014, p=0.02).Conclusion: In this cross-sectional study, levels of amyloid-β load was higher further along the DLB continuum. Whereas amyloid-β levels were comparable to cognitively unimpaired individuals in iRBD, a significant elevation in amyloid-β levels was observed in the pre-dementia stage of MCI-LB and in DLB. Specifically, APOE ε4 carriers had higher amyloid-β levels than APOE ε4 non-carriers and women tended to have higher amyloid-β levels than men as they got older. These findings have important implications in targeting patients within the DLB continuum for clinical trials of disease-modifying therapies. ER -