RT期刊文章SR电子T1β-Amyloid负载宠物沿着连续路易体痴呆的摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。首页0000000000207393 10.1212 / WNL。0000000000207393 A1 Patricia Diaz-Galvan A1斯科特Przybelski A1 (Timothy G Lesnick A1克里斯托弗·G Schwarz A1马修·L Senjem A1 Jeffrey L Gunter A1克利福德·r·杰克A1 Hoon-Ki保罗分钟A1 Manoj Jain A1东寺Miyagawa A1利亚K Forsberg A1朱莉一个字段A1 Rodolfo Savica A1乔纳森Graff-Radford A1大卫·t·琼斯A1雨果·博塔A1埃里克·K·圣路易斯A1 David S Knopman A1 Vijay K Ramanan A1欧文罗斯A1尼尔Graff-Radford A1 Gregory节A1丹尼斯·w·迪克森A1坦尼斯j . Ferman A1罗纳德·C彼得森A1 Val j·劳A1布拉德·F Boeve A1 Kejal Kantarci年2023 UL //www.ez-admanager.com/content/early/2023/05/18/WNL.0000000000207393.abstract AB背景:Amyloid-β斑块可以共现Lewy-related病理学在路易体痴呆患者(下文),但Amyloid-β负载在下文的前首页驱的阶段仍然需要阐明。我们调查amyloid-β负载宠物在下文连续体,从孤立的REM睡眠行为障碍的早期前驱期(iRBD)阶段的轻度认知障碍与路易小体(MCI-LB),最后下文。方法:我们进行了横断面研究患者诊断为iRBD, MCI-LB或下文从梅奥诊所阿尔茨海默病研究中心。Amyloid-β水平衡量匹兹堡化合物B(加以宠物和全球标准皮质吸收价值比率(SUVr)计算。全球皮质加以SUVr值从每个临床组比较,没有个人的认知(铜;n = 100)使用ANCOVA平衡在年龄和性别。我们使用多元线性回归测试交互学习的影响性和APOEε4地位加以SUVr下文连续。结果:162名患者,16 iRBD, 64年MCI-LB,和82年有下文。与铜相比,全球皮质加以SUVr在下文更高(p < 0.001)和MCI-LB (p = 0.012)。下文组包括amyloid-β阳性患者的比例最高(60%),其次是MCI-LB (41%)、iRBD(25%),最后是铜(19%)。全球皮质加以SUVr APOEε4运营商相比,价格高的载脂蛋白eε4非承运人在MCI-LB (p < 0.001)和下文组(p = 0.049)。 Women had higher PiB SUVr with older age compared to men across the DLB continuum (βeta estimate=0.014, p=0.02).Conclusion: In this cross-sectional study, levels of amyloid-β load was higher further along the DLB continuum. Whereas amyloid-β levels were comparable to cognitively unimpaired individuals in iRBD, a significant elevation in amyloid-β levels was observed in the pre-dementia stage of MCI-LB and in DLB. Specifically, APOE ε4 carriers had higher amyloid-β levels than APOE ε4 non-carriers and women tended to have higher amyloid-β levels than men as they got older. These findings have important implications in targeting patients within the DLB continuum for clinical trials of disease-modifying therapies.