PT -期刊文章盟Berta葡萄牙盟——范妮玆哲盟——伊莎贝尔Degaey AU - Emmanuel罗兹AU -艾格尼丝·弗尔涅盟蒋禄卡Severi AU -玛丽安Canonico盟塞西尔Proust-Lima AU - Alexis巴兹TI -协会女性的身体活动和帕金森病:长期随访的- 10.1212 / WNL E3N队列研究援助。0000000000207424 DP - 2023年5月17日TA -神经病首页学PG - 10.1212 / WNL。0000000000207424 4099 - http://n.首页neurology.org/content/early/2023/05/17/WNL.0000000000207424.short 4100 - //www.ez-admanager.com/content/early/2023/05/17/WNL.0000000000207424.full AB -背景和目标:之前的队列研究报道,一个测量的身体活动(PA)评价与帕金森病(PD)的发病率较低,但一个荟萃分析表明,这种联系是局限于男性。由于疾病的前驱期长,反向因果关系不能排除作为一个可能的解释。我们的目标是研究时变PA和PD使用滞后分析之间的关系来解决潜在的反向因果关系,和之前比较PA轨迹的病人诊断和匹配控制。方法:我们使用数据从E3N(1990 - 2018),一个队列研究的女性隶属于国家健康保险计划的人在教育工作。爸爸是自我报告的后续六个调查问卷。随着问卷问题发生了变化,我们创建了一个时变潜伏PA (LPA)变量使用潜在过程混合模型。PD确定使用多步验证过程是基于医疗记录,或基于药物声称的验证算法。我们设置一个嵌套病例对照研究来考察LPA轨迹的差异使用多变量线性混合模型和回顾的时间尺度。Cox比例风险模型随着年龄的时间表和调整混杂因素被用来估计时变LPA和PD发病率之间的关系。我们主要分析10 y-lag账户用于反向因果关系; sensitivity analyses used 5y, 15y, and 20y-lags.Results: Analyses of trajectories (1,196 cases, 23,879 controls) showed that LPA was significantly lower in cases than in controls throughout the follow-up, including 29y before diagnosis; the difference between cases and controls started to increase ∼10y before diagnosis (P-interaction=0.003). In our main survival analysis, of 95,354 women free of PD in 2000, 1,074 women developed PD over a mean follow-up of 17.2y. PD incidence decreased with increasing LPA (P-trend=0.001), with 25% lower incidence in those in the highest quartile compared to the lowest (adjusted hazard ratio=0.75, 95% confidence interval=0.63-0.89). Using longer lags yielded similar conclusions.Discussion: Higher PA level is associated with lower PD incidence in women, not explained by reverse causation. These results are important for planning interventions for PD prevention.

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