RT SR电子条T1协会》杂志上APOE4、骨关节炎、β-Amyloid和τ积累在阿尔茨海默病主要运动和躯体感觉区摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。首页0000000000207369 10.1212 / WNL。李0000000000207369 A1杜京A1 Anqi A1戴施A1徐汇陈A1 Qingyong王A1刘甄A1库恩太阳A1郭腾飞年2023 UL //www.ez-admanager.com/content/early/2023/05/13/WNL.000000000020首页7369.abstract AB背景和目标:最常见的慢性疾病之一,骨关节炎,可能与载脂蛋白E-ε4 (APOE-ε4)加速阿尔茨海默病(AD)的改变,尤其是在初级运动(前)和躯体感觉皮层(中央后)。要理解这背后的原因,我们研究了骨关节炎和APOE-ε4如何影响的积累β-amyloid (Aβ)和τ积累在初级运动和躯体感觉区Aβ-positive (Aβ+)老年人。方法:我们选择Aβ+阿尔茨海默病的神经影像学参与者定义的基线18 f-florbetapir (FBP) Aβ宠物标准吸收价值比率(SUVR)广告总结皮质区域,纵向Aβ宠物,骨关节炎病史记录和APOE-ε4基因分型。我们检查了骨关节炎和APOE-ε4如何与基线和纵向Aβ积累,τ沉积以后续在中央前和中央后皮质,以及他们如何调节Aβ-associated未来τ水平较高,调整了年龄、性别、诊断和使用多个比较修正。结果:374人(平均年龄75,49.2%为女性,62.8% APOE-ε4载体)进行了纵向FBP宠物的平均随访3.3年(四分位范围(差)3.4,1.6∼9.4)进行了分析,并有96人18 f-flortaucipir (FTP)τ宠物以中位数为5.4(差1.9,4.0∼9.3)年post-baseline FBP宠物。骨关节炎和APOE-ε4与基线FBP SUVR在中央前和中央后区域。在随访,骨关节炎而不是APOE-ε4与快Aβ积累在中央后(β= 0.005(95%可信区间,0.001,0.008))。此外,骨关节炎而不是APOE-ε4等位基因关系密切随访FTPτ水平较高的中央前(β= 0.098(95%可信区间,0.034,0.162))和中央后(β= 0.105(95%可信区间,0.040,0.169))皮质。OA和APOE-ε4也交互与更高的后续FTPτ沉积在中央前(β= 0.128(95%可信区间,0.030,0.226))和中央后(β= 0.124(95%可信区间,0.027,0.223))地区。Discussion: This study suggests that OA was associated with faster Aβ accumulation and higher Aβ-dependent future tau deposition in primary motor and somatosensory regions, providing novel insights into how OA increases the risk of AD.Glossary: Aβ: β-amyloid; AD: Alzheimer’s disease; CU: cognitively unimpaired; CI: cognitively impaired; MCI: mild cognitive impairment; OA: osteoarthritis; FBP: 18F-florbetapir; FTP: 18F-flortaucipir; PET: Positron emission tomography; SUVR: Standard uptake value ratio