TY -的T1 - CSF突触生物标志物在(N)的子组路易身体疾病的JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207371 SP - 10.1212 / WNL。0000000000207371 AU -洛伦佐Barba盟萨米尔Abu-Rumeileh AU - Steffen Halbgebauer盟Giovanni Bellomo盟费德里科•保利Paoletti Patrick Oeckl AU -洛伦佐Gaetani盟盟-佩特拉Steinacker盟费德里科•马萨AU -露西拉Parnetti AU -马库斯·奥托Y1 - 2023/05/15 UR - //www.ez-admanager.com/content/early/2023/05/13/WNL.0000000000207371.abstract N2 -背景和目首页标。路易的身体疾病患者(精神的小黑裙)经常显示共病的阿尔茨海默病(AD)病理学。脑脊液(CSF)生物标记允许检测体内AD-related病理特征包括在(N)分类系统。这里,我们旨在调查CSF突触和neuro-axonal损伤的生物标记是否与广告co-pathology面前的小黑裙,可以有助于区分的小黑裙在(N) profiles.Methods患者不同。我们回顾性测定CSF水平的广告核心生物标志物(Aβ42/40比率,p-tau t-tau)和突触(β-synuclein、α-synuclein SNAP-25, neurogranin)和neuro-axonal蛋白质(NfL)在28认知没有参与者non-degenerative神经疾病和诊断的161名参与者的小黑裙或广告(在轻度认知障碍、AD-MCI和痴呆阶段,AD-dem)。我们在临床脑脊液生物标志物的水平相比,在(N)的subgroups.Results。CSFβ-synuclein,α-synuclein、SNAP-25 neurogranin和NfL水平没有差异的小黑裙(n = 101 = 67.2±7.8岁,27.7%的女性)和控制(= 64.8±8.6岁,39.3%的女性),增加广告(AD-MCI n = 30, AD-dem n = 30日= 72.3±6.0岁,女性63.3%)相比,两组(p & lt;0.001所有比较)。在小黑裙),我们发现增加突触和neuro-axonal变性患者的生物标记A + T +(小黑裙/ A + T +)与T -概要(小黑裙/ T) (p & lt; 0.01 for all), and β-synuclein showed the highest discriminative accuracy between the two groups (AUC = 0.938, 95%CI = 0.884 - 0.991). CSF β-synuclein (p = 0.0021), α-synuclein (p = 0.0099) and SNAP-25 concentrations (p = 0.013) were also higher in LBD/A+T+ than in LBD/A+T- cases, which had synaptic biomarkers levels within the normal range. CSF α-synuclein was significantly decreased only in LBD patients with T- profiles compared to controls (p = 0.0448). Moreover, LBD/A+T+ and AD cases did not differ in any biomarker level.Discussion. LBD/A+T+ and AD cases showed significantly increased CSF levels of synaptic and neuro-axonal biomarkers compared to LBD/A-T- and control subjects. LBD patients with AD co-pathology might, thus, experience similar degrees of synaptic dysfunction than pure AD cases.Classification of evidence. This study provides Class II evidence that CSF levels of β-synuclein, α-synuclein, SNAP-25, neurogranin and NfL are higher in patients with AD than in patients with LBD. ER -