RT期刊文章SR电子T1 CSF突触生物标志物在路易身体疾病的(N)的子组摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。首页0000000000207371 10.1212 / WNL。0000000000207371 A1洛伦佐Barba A1萨米尔Abu-Rumeileh A1 Steffen Halbgebauer A1 Giovanni Bellomo A1费德里科•保利Paoletti A1洛伦佐Gaetani A1帕特里克Oeckl A1 Petra Steinacker A1费德里科•马萨A1露西拉Parnetti A1马库斯·奥托年2023 UL //www.ez-admanager.com/content/early/2023/05/13/WNL.0000000000207首页371.abstract AB背景和目标。路易的身体疾病患者(精神的小黑裙)经常显示共病的阿尔茨海默病(AD)病理学。脑脊液(CSF)生物标记允许检测体内AD-related病理特征包括在(N)分类系统。这里,我们旨在调查CSF突触和neuro-axonal损伤的生物标记是否与广告co-pathology面前的小黑裙,可以有助于区分的小黑裙在(N) profiles.Methods患者不同。我们回顾性测定CSF水平的广告核心生物标志物(Aβ42/40比率,p-tau t-tau)和突触(β-synuclein、α-synuclein SNAP-25, neurogranin)和neuro-axonal蛋白质(NfL)在28认知没有参与者non-degenerative神经疾病和诊断的161名参与者的小黑裙或广告(在轻度认知障碍、AD-MCI和痴呆阶段,AD-dem)。我们在临床脑脊液生物标志物的水平相比,在(N)的subgroups.Results。CSFβ-synuclein,α-synuclein、SNAP-25 neurogranin和NfL水平没有差异的小黑裙(n = 101 = 67.2±7.8岁,27.7%的女性)和控制(= 64.8±8.6岁,39.3%的女性),增加广告(AD-MCI n = 30, AD-dem n = 30日= 72.3±6.0岁,女性63.3%)相比,所有比较两组(p < 0.001)。在小黑裙),我们发现增加突触和neuro-axonal变性患者的生物标记A + T +(小黑裙/ A + T +)与T -概要(小黑裙/ T -) (p < 0.01),β-synuclein显示,两组之间的区别的最高精度(AUC = 0.938, 95% ci = 0.884 - 0.991)。CSFβ-synuclein (p = 0.0021),α-synuclein (p = 0.0099)和SNAP-25浓度(p = 0.013)也在小黑裙/ A + T +高于在小黑裙/ A + T -情况下,曾突触生物标记物的水平在正常范围内。 CSF α-synuclein was significantly decreased only in LBD patients with T- profiles compared to controls (p = 0.0448). Moreover, LBD/A+T+ and AD cases did not differ in any biomarker level.Discussion. LBD/A+T+ and AD cases showed significantly increased CSF levels of synaptic and neuro-axonal biomarkers compared to LBD/A-T- and control subjects. LBD patients with AD co-pathology might, thus, experience similar degrees of synaptic dysfunction than pure AD cases.Classification of evidence. This study provides Class II evidence that CSF levels of β-synuclein, α-synuclein, SNAP-25, neurogranin and NfL are higher in patients with AD than in patients with LBD.

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