TY - T1的临床表现和预后患者急性营养轴突神经病变JF -神经学乔-神经病学SP - e2134 LP - e2140做- 10.1212 / WNL。首页0000000000207215六世- 100 - 20 AU -约翰娜。哈默尔盟埃里克·l·Logigian Y1 - 2023/05/16 UR - //www.ez-admanager.com/content/首页100/20/e2134.abstract N2 -背景和目标描述的临床,微量营养素,电生理学的光谱和急性营养轴突神经病变患者的预后(安安)。方法患者的死因被确定在1999年和2020年之间的回顾性研究的EMG数据库和电子健康记录和分类的临床和电诊法的理由,作为纯粹的感觉,感觉运动,或纯粹的电动机;和风险因素(酒精使用障碍,减肥手术,或厌食症)。实验室异常记录包括硫胺素,维生素B6, B12和维生素E,叶酸和铜。步和神经性疼痛状态最后随访记录。结果患者40安安,21个酒精使用障碍,10个厌食症患者,9最近经历了减肥手术。他们的神经病变是纯粹的感官在14低硫胺素(7),在23个低硫胺素(8),感觉运动和纯电机3与低硫胺(1)。维生素B1是最常见的低(85%),其次是维生素B6(77%)和叶酸(50%)。风险因素和神经病变类型并不与特定微量营养素缺乏关联。37岁的患者在随访中,只有13(35%)独立行走,疼痛,只有8(22%)在最后的随访中自由的意思是22个月(范围2 - 88个月)从发病。Discussion The spectrum of ANAN is wide, ranging from: (1) a pure sensory neuropathy with areflexia, limb and gait ataxia, neuropathic pain, and unevocable sensory responses to (2) a motor axonal neuropathy with low-amplitude motor responses without conduction slowing, block, or dispersion, and (3) a mixed sensorimotor axonal polyneuropathy. Specific micronutrient deficiencies or risk factors do not predict neuropathy subtype. The subgroup of patients with ANAN with documented thiamine deficiency also range from pure sensory to pure motor, and only a minority have Wernicke encephalopathy. We do not know whether coexistent micronutrient deficiencies may help explain the wide clinical spectrum of thiamine-deficient ANAN. The prognosis of ANAN is guarded due to residual neuropathic pain and slow recovery of independent ambulation. Therefore, early recognition of patients at risk is important.ANAN=acute nutritional axonal neuropathy; GBS=Guillain-Barre syndrome; GI=gastrointestinal; IVIg=IV immunoglobulin; MCV=mean corpuscular volume ER -