PT -期刊文章盟阿梅利亚希克斯AU -本杰明·辛克莱盟桑迪舒尔茨AU -威廉Pham盟盟丽莎C希尔伯特Daniel L施瓦茨AU -克里斯托弗·C罗盟-珍妮L Ponsford AU -孟法盟-革顺施皮茨TI -协会扩大血管周的空间与脑损伤、脑年龄和临床结果在慢性创伤性脑损伤- 10.1212 / WNL援助。0000000000207370 DP - 2023可能08年TA -神经病学首页PG - 10.1212 / WNL。0000000000207370 4099 - http://n.首页neurology.org/content/early/2023/05/08/WNL.0000000000207370.short 4100 - //www.ez-admanager.com/content/early/2023/05/08/WNL.0000000000207370.full AB -背景和目标扩大血管周的空间(ePVS)已经被认定为一个重要的签名glymphatic系统功能障碍的神经疾病。的发病率和临床意义ePVS创伤性脑损伤(TBI)后还不理解。我们调查是否患有慢性moderate-severe创伤性脑损伤ePVS负担的增加,以及是否ePVS负担调制的存在局部病变,大脑年龄老,睡眠质量差。我们检查是否增加负担ePVS与贫穷有关认知和情感的结果。方法采用横断面设计中,参与者与单个moderate-severe慢性创伤性脑损伤(持续≥10年前)招募了住院康复计划。控制从社区招募参与者。参与者进行了脑磁共振3 t、神经心理评估和临床评价。ePVS负担在白质量化使用自动分割。组成员ePVS数量之间的关系,局部病变,大脑年龄,现在的睡眠质量,使用负二项模型和线性回归结果。结果这个研究包括了100名参与者和创伤性脑损伤(男性70%; M = 56.8 years), and 75 control participants (54.3% male; M = 59.8 years). The TBI group had a significantly greater burden of ePVS (prevalence ratio rate (PRR) = 1.29, p = 0.013, CI95% [1.05, 1.57]). The presence of bilateral lesions was associated with greater ePVS burden (PRR = 1.41, p = 0.021, CI95% [1.05, 1.90]). There was no association between ePVS burden, sleep quality (PRR = 1.01, p = 0.491, CI95% [0.98, 1.048]) and sleep duration (PRR = 1.03, p = 0.556, CI95% [0.92, 1.16]). ePVS was associated with verbal memory (β = -0.42, p = 0.006, CI95% [-0.72, -0.12]), but not with other cognitive domains. Burden of ePVS was not associated with emotional distress (β = -0.70, p = 0.461, CI95% [-2.57, 1.17) or brain age (PRR = 1.00, p = 0.665, CI95% [0.99, 1.02]).Discussion TBI is associated with a greater burden of ePVS, especially when there have been bilateral brain lesions. ePVS was associated with reduced verbal memory performance. ePVS may indicate ongoing impairments in glymphatic system function in the chronic post-injury period.

map