@article {Hicks10.1212 / WNL。0000000000207370,作者={阿米莉亚希克斯和本杰明·辛克莱尔和桑迪舒尔茨和威廉·范教授和丽莎和丹尼尔·L C希尔伯特施瓦茨和克里斯托弗·C罗和珍妮L Ponsford和孟法和革顺猎犬},title ={协会扩大血管周的空间与脑损伤、脑年龄,和慢性创伤性脑损伤的临床结果},elocation-id = {10.1212 / WNL。={2023}0000000000207370},年,doi = {10.1212 / WNL。出版商0000000000207370}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标扩大血管周的空间(ePVS)已经被认定为一个重要的签名glympha首页tic系统功能障碍的神经疾病。的发病率和临床意义ePVS创伤性脑损伤(TBI)后还不理解。我们调查是否患有慢性moderate-severe创伤性脑损伤ePVS负担的增加,以及是否ePVS负担调制的存在局部病变,大脑年龄老,睡眠质量差。我们检查是否增加负担ePVS与贫穷有关认知和情感的结果。方法采用横断面设计中,参与者与单个moderate-severe慢性创伤性脑损伤(持续> = 10年前)招募了住院康复计划。控制从社区招募参与者。参与者进行了脑磁共振3 t、神经心理评估和临床评价。ePVS负担在白质量化使用自动分割。 The relationship between number of ePVS, group membership, focal lesions, brain age, current sleep quality, and outcome was modelled using negative binomial and linear regressions.Results This study included 100 participants with TBI (70\% male; M = 56.8 years), and 75 control participants (54.3\% male; M = 59.8 years). The TBI group had a significantly greater burden of ePVS (prevalence ratio rate (PRR) = 1.29, p = 0.013, CI95\% [1.05, 1.57]). The presence of bilateral lesions was associated with greater ePVS burden (PRR = 1.41, p = 0.021, CI95\% [1.05, 1.90]). There was no association between ePVS burden, sleep quality (PRR = 1.01, p = 0.491, CI95\% [0.98, 1.048]) and sleep duration (PRR = 1.03, p = 0.556, CI95\% [0.92, 1.16]). ePVS was associated with verbal memory (β = -0.42, p = 0.006, CI95\% [-0.72, -0.12]), but not with other cognitive domains. Burden of ePVS was not associated with emotional distress (β = -0.70, p = 0.461, CI95\% [-2.57, 1.17) or brain age (PRR = 1.00, p = 0.665, CI95\% [0.99, 1.02]).Discussion TBI is associated with a greater burden of ePVS, especially when there have been bilateral brain lesions. ePVS was associated with reduced verbal memory performance. ePVS may indicate ongoing impairments in glymphatic system function in the chronic post-injury period.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/early/2023/05/08/WNL.0000000000207370}, eprint = {//www.ez-admanager.com/content/early/2023/05/08/WNL.0000000000207370.full.pdf}, journal = {Neurology} }