TY - T1的发作负担和神经结果后新生儿脑病JF -神经学乔-神经病学SP - e1976 LP - e1984做- 10.1212 / WNL。首页0000000000207202六世- 100 - 19盟Huda m . Alharbi AU -伊莱·Pinchefsky盟我俺Tran AU -卡洛斯·伊万Salazar Cerda先生盟杰西Parokaran Varghese盟——达芙妮Kamino盟Elysa Widjaja盟- Eva Mamak盟灵Ly盟Paivi Nevalainen AU -塞西尔·d·哈恩盟艾米丽W.Y. Tam Y1 - 2023/05/09 UR - //www.ez-admanager.com/content/100/19/e1976.abstract N2 -背景和目标发作期间常见的新生儿脑病(NE),但发作负担(某人)结果的首页贡献仍然是有争议的。本研究旨在研究NE后电记录的某人和神经的结果之间的关系。方法前瞻性群组研究招募了新生儿≥36周postmenstrual年龄大约6个小时的生活2014年8月至2019年11月从新生儿重症监护室(NICU)。参与者进行了连续脑电图至少48小时,大脑核磁共振在3 - 5天内的生活,和结构化随访18个月。电记录的癫痫发作被确定执照神经生理学和量化总某人和最大小时。药物接触分数计算基于NICU住院期间所有抗癫痫药物。大脑MRI损伤严重程度分类是基于基底神经节和流域的分数。发展成果使用婴儿发展的量表测量,第三版。多变量回归分析,调整重大潜在的混杂因素。结果108登记婴儿,98年连续脑电图(cEEG)和核磁共振数据收集,其中5例失访,6岁之前死亡18个月。 All infants with moderate-severe encephalopathy completed therapeutic hypothermia. cEEG-confirmed neonatal seizures occurred in 21 (24%) newborns, with a total SB mean of 12.5 ± 36.4 minutes and a maximum hourly SB mean of 4 ± 10 min/h. After adjusting for MRI brain injury severity and medication exposure, total SB was significantly associated with lower cognitive (−0.21, 95% CI −0.33 to −0.08, p = 0.002) and language (−0.25, 95% CI −0.39 to −0.11, p = 0.001) scores at 18 months. Total SB of 60 minutes was associated with 15-point decline in language scores and 70 minutes for cognitive scores. However, SB was not significantly associated with epilepsy, neuromotor score, or cerebral palsy (p > 0.1).Discussion Higher SB during NE was independently associated with worse cognitive and language scores at 18 months, even after adjusting for exposure to antiseizure medications and severity of brain injury. These observations support the hypothesis that neonatal seizures occurring during NE independently contribute to long-term outcomes.Bayley-3=Bayley Scales of Infant and Toddler Development, Third Edition; cEEG=continuous EEG; NE=neonatal encephalopathy; NICU=neonatal intensive care unit; SB=seizure burden ER -