RT期刊文章SR电子T1发作负担和神经结果后新生儿脑病摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e1976 OP e1984 10.1212 / WNL。首页100签证官0000000000207202 19岁A1 Huda m . Alharbi A1伊f . Pinchefsky A1我俺Tran A1卡洛斯·伊万Salazar Cerda先生A1杰西Parokaran Varghese A1达芙妮Kamino A1 Elysa Widjaja A1 Eva Mamak A1灵Ly A1 Paivi Nevalainen A1塞西尔·d·哈恩A1艾米丽W.Y. Tam年2023 UL //www.ez-admanager.com/content/100/19/e1976.abstract AB背景首页和目标发作期间常见的新生儿脑病(NE),但发作负担(某人)结果的贡献仍然是有争议的。本研究旨在研究NE后电记录的某人和神经的结果之间的关系。方法前瞻性群组研究招募了新生儿≥36周postmenstrual年龄大约6个小时的生活2014年8月至2019年11月从新生儿重症监护室(NICU)。参与者进行了连续脑电图至少48小时,大脑核磁共振在3 - 5天内的生活,和结构化随访18个月。电记录的癫痫发作被确定执照神经生理学和量化总某人和最大小时。药物接触分数计算基于NICU住院期间所有抗癫痫药物。大脑MRI损伤严重程度分类是基于基底神经节和流域的分数。发展成果使用婴儿发展的量表测量,第三版。多变量回归分析,调整重大潜在的混杂因素。结果108登记婴儿,98年连续脑电图(cEEG)和核磁共振数据收集,其中5例失访,6岁之前死亡18个月。 All infants with moderate-severe encephalopathy completed therapeutic hypothermia. cEEG-confirmed neonatal seizures occurred in 21 (24%) newborns, with a total SB mean of 12.5 ± 36.4 minutes and a maximum hourly SB mean of 4 ± 10 min/h. After adjusting for MRI brain injury severity and medication exposure, total SB was significantly associated with lower cognitive (−0.21, 95% CI −0.33 to −0.08, p = 0.002) and language (−0.25, 95% CI −0.39 to −0.11, p = 0.001) scores at 18 months. Total SB of 60 minutes was associated with 15-point decline in language scores and 70 minutes for cognitive scores. However, SB was not significantly associated with epilepsy, neuromotor score, or cerebral palsy (p > 0.1).Discussion Higher SB during NE was independently associated with worse cognitive and language scores at 18 months, even after adjusting for exposure to antiseizure medications and severity of brain injury. These observations support the hypothesis that neonatal seizures occurring during NE independently contribute to long-term outcomes.Bayley-3=Bayley Scales of Infant and Toddler Development, Third Edition; cEEG=continuous EEG; NE=neonatal encephalopathy; NICU=neonatal intensive care unit; SB=seizure burden